Use of the beta-lactamase inhibitor clavulanic acid in the isolation of auxotrophic mutants of Bacillus licheniformis

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC215723/

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http://hdl.handle.net/11603/13275

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UMBC Biological Sciences Department
UMBC Department of Marine Biotechnology

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1984-08

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journal articles
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Citation of Original Publication

P I Fields, H J Schreier, A L Saha, and R W Bernlohr, Use of the beta-lactamase inhibitor clavulanic acid in the isolation of auxotrophic mutants of Bacillus licheniformis., J Bacteriol. 1984 Aug; 159(2): 803–804, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC215723/

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Subjects

Bacillus licheniformis
beta-lactamase activity
clavulanic acid and cefotaxime

Abstract

The isolation of auxotrophic mutants of Bacillus licheniformis, a microbe containing constitutive ,β-lactamase activity, was found to be facilitated by the addition of clavulanic acid and cefotaxime during enrichment.