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    An extracellular matrix protein prevents cytokinesis failure and aneuploidy in the C. elegans germline

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    https://www.ncbi.nlm.nih.gov/pubmed/21558805
    Permanent Link
    https://dx.doi.org/10.4161%2Fcc.10.12.15896
    http://hdl.handle.net/11603/13929
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    • UMBC Biological Sciences Department
    • UMBC Faculty Collection
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    Author/Creator
    Vogel, Bruce E.
    Wagner, Cynthia R.
    Paterson, Joanna Mathis
    Xu, Xuehong
    Yanowitz, Judith L.
    Date
    2011-06-15
    Type of Work
    5 pages
    Text
    journal articles
    Citation of Original Publication
    Bruce E Vogel, Cynthia Wagner, et.al, An extracellular matrix protein prevents cytokinesis failure and aneuploidy in the C. elegans germline, Cell Cycle. 2011 Jun 15; 10(12): 1916–1920, https://dx.doi.org/10.4161%2Fcc.10.12.15896
    Rights
    This item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
    Subjects
    aneuploidy
    cytokinesis
    extracellular matrix
    C. elegans
    cleavage furrow
    hemicentin
    tetraploid intermediate
    Abstract
    Interactions between extracellular matrix (ECM) proteins and their transmembrane receptors mediate cytoskeletal reorganization and corresponding changes in cell shape during cell migration, adhesion, differentiation and polarization. Cytokinesis is the final step in cell division as cells employ a contractile ring composed of actin and myosin to partition one cell into two. Cells undergo dramatic changes in cell shape during the division process, creating new membrane and forming an extracellular invagination called the cleavage furrow. However, existing models of cytokinesis include no role for the ECM. In a recent paper, we demonstrate that depletion of a large secreted protein, hemicentin, results in membrane destabilization, cleavage furrow retraction and cytokinesis failure in C. elegans germ cells and in preimplantation mouse embryos. Here, we demonstrate that cytokinesis failure produces tetraploid intermediate cells with multipolar spindles, providing a potential explanation for the large number of aneuploid progeny observed among C. elegans hemicentin mutant hermaphrodites.


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    Albin O. Kuhn Library & Gallery
    University of Maryland, Baltimore County
    1000 Hilltop Circle
    Baltimore, MD 21250
    www.umbc.edu/scholarworks

    Contact information:
    Email: scholarworks-group@umbc.edu
    Phone: 410-455-3544


    If you wish to submit a copyright complaint or withdrawal request, please email mdsoar-help@umd.edu.