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dc.contributor.authorVogel, Bruce E.
dc.contributor.authorWagner, Cynthia R.
dc.contributor.authorPaterson, Joanna Mathis
dc.contributor.authorXu, Xuehong
dc.contributor.authorYanowitz, Judith L.
dc.description.abstractInteractions between extracellular matrix (ECM) proteins and their transmembrane receptors mediate cytoskeletal reorganization and corresponding changes in cell shape during cell migration, adhesion, differentiation and polarization. Cytokinesis is the final step in cell division as cells employ a contractile ring composed of actin and myosin to partition one cell into two. Cells undergo dramatic changes in cell shape during the division process, creating new membrane and forming an extracellular invagination called the cleavage furrow. However, existing models of cytokinesis include no role for the ECM. In a recent paper, we demonstrate that depletion of a large secreted protein, hemicentin, results in membrane destabilization, cleavage furrow retraction and cytokinesis failure in C. elegans germ cells and in preimplantation mouse embryos. Here, we demonstrate that cytokinesis failure produces tetraploid intermediate cells with multipolar spindles, providing a potential explanation for the large number of aneuploid progeny observed among C. elegans hemicentin mutant hermaphrodites.en_US
dc.description.sponsorshipThis work was supported by grants from the National Science Foundation (MCB1038902) and National Institutes of Health (GM65184). J.M.P. was supported by Training Grant T32HL072751.en_US
dc.format.extent5 pagesen_US
dc.genrejournal articlesen_US
dc.identifier.citationBruce E Vogel, Cynthia Wagner,, An extracellular matrix protein prevents cytokinesis failure and aneuploidy in the C. elegans germline, Cell Cycle. 2011 Jun 15; 10(12): 1916–1920,
dc.publisherTaylor & Francisen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Biological Sciences Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.subjectextracellular matrixen_US
dc.subjectC. elegansen_US
dc.subjectcleavage furrowen_US
dc.subjecttetraploid intermediateen_US
dc.titleAn extracellular matrix protein prevents cytokinesis failure and aneuploidy in the C. elegans germlineen_US

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