ScholarWorks@UMBC
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ScholarWorks@UMBC, a part of MD-SOAR (The Maryland Shared Open Access Repository), collects, preserves, and provides public access to the scholarly output of the University of Maryland, Baltimore County (UMBC). Community members can upload research products for rapid dissemination, global visibility and impact, and long-term preservation.
You can use ScholarWork@UMBC to share and preserve a wide range of research products, such as articles, papers, books, and technical reports. To get started, review our short guide to submitting, here.
All UMBC academic and administrative departments are eligible to have their own unique page set up in the repository for their materials. Departments that don't yet have their own page can contact call 410-455-3021 or e-mail scholarworks-group@umbc.edu to get a page set up.
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About UMBC and Its People
This collection consists of links to articles about UMBC or people affiliated with UMBC.
Recent Submissions
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The True Romance of W.E.B. Du Bois’s Dark Princess
W.E.B Du Bois’s 1928 novel Dark Princess has had a long and contradictory reception. On the one hand, scholars admire how it offers a prescient model of the possibilities in our own time of intergroup solidarity as well ... -
Functional nonequality of the cardiac and skeletal ryanodine receptors
(1997-02-04)Dihydropyridine receptors (DHPRs), which are voltage-gated Ca2+ channels, and ryanodine receptors (RyRs), which are intracellular Ca2+ release channels, are expressed in diverse cell types, including skeletal and cardiac ... -
Bitter Taste Transduction of Denatonium in the MudpuppyNecturus maculosus
(Society for Neuroscience, 1997-05-15)Bitter substances are a structurally diverse group of compounds that appear to act via several transduction mechanisms. The bitter-tasting denatonium ion has been proposed to act via two different G-protein-regulated ... -
IP3-Independent Release of Ca2+ From Intracellular Stores: A Novel Mechanism for Transduction of Bitter Stimuli
(American Physiological Society (APS), 1999-11-01)A variety of substances with different chemical structures elicits a bitter taste. Several different transduction mechanisms underlie detection of bitter tastants; however, these have been described in detail for only a ... -
Neural Networks Distinguish between Taste Qualities Based on Receptor Cell Population Responses
(Oxford Academic, 2001-06-01)Response features of taste receptor cell action potentials were examined using an artificial neural network to determine whether they contain information about taste quality. Using the loose patch technique to record from ... -
Maintenance of Rat Taste Buds in Primary Culture
(Oxford Academic, 2001-09-01)The differentiated taste bud is a complex end organ consisting of multiple cell types with various morphological, immunocytochemical and electrophysiological characteristics. Individual taste cells have a limited lifespan ... -
Acetylcholine Increases Intracellular Ca2+ in Taste Cells Via Activation of Muscarinic Receptors
(American Physiological Society (APS), 2002-06-01)Previous studies suggest that acetylcholine (ACh) is a transmitter released from taste cells as well as a transmitter in cholinergic efferent neurons innervating taste buds. However, the physiological effects on taste cells ... -
Taste Receptor Cell Responses to the Bitter Stimulus Denatonium Involve Ca2+ Influx Via Store-Operated Channels
(American Physiological Society (APS), 2002-06-01)Previous studies in rat and mouse have shown that brief exposure to the bitter stimulus denatonium induces an increase in [Ca2+]i due to Ca2+ release from intracellular Ca2+ stores, rather than Ca2+influx. We report here ... -
Acid-Activated Cation Currents in Rat Vallate Taste Receptor Cells
(American Physiological Society (APS), 2002-07-01)Sour taste is mediated by acids with the degree of sourness a function of proton concentration. Recently, several members of the acid-sensing ion channel subfamily (ASICs) were cloned from taste cells and proposed to mediate ... -
Responses to Di-Sodium Guanosine 5′-Monophosphate and Monosodiuml-Glutamate in Taste Receptor Cells of Rat Fungiform Papillae
(American Physiological Society (APS), 2003-03-01)The 5′-ribonucleotide guanosine 5′-monophosphate (GMP) is used widely as an umami taste stimulus and a potent flavor enhancer as it synergistically increases the umami taste elicited by monosodium glutamate. Transduction ... -
TRPM5-Expressing Solitary Chemosensory Cells Respond to Odorous Irritants
(American Physiological Society (APS), 2008-03-01)Inhaled airborne irritants elicit sensory responses in trigeminal nerves innervating the nasal epithelium, leading to protective reflexes. The sensory mechanisms involved in the detection of odorous irritants are poorly ... -
Vagal gustatory reflex circuits for intraoral food sorting behavior in the goldfish: Cellular organization and neurotransmitters
(Wiley, 2009-09-20)The sense of taste is crucial in an animal's determination as to what is edible and what is not. This gustatory function is especially important in goldfish, who utilize a sophisticated oropharyngeal sorting mechanism to ... -
Chemoreception Regulates Chemical Access to Mouse Vomeronasal Organ: Role of Solitary Chemosensory Cells
(PLOS, 2010-07-30)Controlling stimulus access to sensory organs allows animals to optimize sensory reception and prevent damage. The vomeronasal organ (VNO) detects pheromones and other semiochemicals to regulate innate social and sexual ... -
Cholinergic microvillous cells in the mouse main olfactory epithelium and effect of acetylcholine on olfactory sensory neurons and supporting cells
(American Physiological Society (APS), 2011-09-01)The mammalian olfactory epithelium is made up of ciliated olfactory sensory neurons (OSNs), supporting cells, basal cells, and microvillous cells. Previously, we reported that a population of nonneuronal microvillous cells ... -
Automated measurement of nerve fiber density using line intensity scan analysis
(Elsevier, 2012-05-15)Quantification of nerve fibers in peripheral and central nervous systems is important for the understanding of neuronal function, organization and pathological changes. However, current methods to quantify nerve fibers are ... -
An Effective Manual Deboning Method To Prepare Intact Mouse Nasal Tissue With Preserved Anatomical Organization
(JoVE, 2013-08-10)The mammalian nose is a multi-functional organ with intricate internal structures. The nasal cavity is lined with various epithelia such as olfactory, respiratory, and squamous epithelia which differ markedly in anatomical ... -
Skn-1a/Pou2f3 is required for the generation of Trpm5-expressing microvillous cells in the mouse main olfactory epithelium
(BMC, 2014-01-16)Background The main olfactory epithelium (MOE) in mammals is a specialized organ to detect odorous molecules in the external environment. The MOE consists of four types of cells: olfactory sensory neurons, supporting ... -
Increases in intracellular calcium via activation of potentially multiple phospholipase C isozymes in mouse olfactory neurons
(Frontiers Media, 2014-10-21)Phospholipase C (PLC) and internal Ca²⁺ stores are involved in a variety of cellular functions. However, our understanding of PLC in mammalian olfactory sensory neurons (OSNs) is generally limited to its controversial role ... -
Dichotomous Distribution of Putative Cholinergic Interneurons in Mouse Accessory Olfactory Bulb
(Frontiers Media, 2017-02-27)Sensory information processing in the olfactory bulb (OB) relies on diverse populations of bulbar interneurons. In rodents, the accessory OB (AOB) is divided into two bulbar regions, the anterior (aAOB) and posterior (pAOB), ... -
Lack of TRPM5-Expressing Microvillous Cells in Mouse Main Olfactory Epithelium Leads to Impaired Odor-Evoked Responses and Olfactory-Guided Behavior in a Challenging Chemical Environment
(Society for Neuroscience, 2017-06-05)The mammalian main olfactory epithelium (MOE) modifies its activities in response to changes in the chemical environment. This process is essential for maintaining the functions of the olfactory system and the upper airway. ...
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