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    Transcriptional control of the S10 ribosomal protein operon of Escherichia coli after a shift to higher temperature

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    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC219091/
    Permanent Link
    http://hdl.handle.net/11603/14015
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    • UMBC Biological Sciences Department
    • UMBC Faculty Collection
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    Author/Creator
    Zengel, J. M.
    Lindahl, L.
    Date
    1985-07
    Type of Work
    8 pages
    Text
    journal articles
    Citation of Original Publication
    J M Zengel and L Lindahl, Transcriptional control of the S10 ribosomal protein operon of Escherichia coli after a shift to higher temperature, J Bacteriol. 1985 Jul; 163(1): 140–147, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC219091/
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    This item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
    Subjects
    S10 ribosomal protein
    Escherichia coli
    guanosine tetraphosphate (ppGpp)
    Abstract
    In the 5 to 10 min immediately following a shift from 30 to 42 degrees C, the differential synthesis rates of ribosomal proteins encoded by the 11-gene S10 operon are transiently decreased. This effect results largely from a two- to threefold decrease in the differential rate of transcription of the operon. The inhibition of mRNA synthesis is apparently due to two types of control: (i) initiation of transcription at the S10 promoter is inhibited and (ii) readthrough at the attenuator in the S10 leader is decreased. Both of these effects on transcription are independent of the heat shock regulatory gene, htpR. Furthermore, the inhibition of transcription is observed in both relA+ and relA cells, suggesting that the temperature-induced repression does not require the relA-dependent accumulation of guanosine tetraphosphate (ppGpp). However, recovery from the heat shock was slower in relA+ strains than in relA strains. None of the other ribosomal protein operons that we analyzed showed such a strong decrease in transcription after the heat shock.


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    Albin O. Kuhn Library & Gallery
    University of Maryland, Baltimore County
    1000 Hilltop Circle
    Baltimore, MD 21250
    www.umbc.edu/scholarworks

    Contact information:
    Email: scholarworks-group@umbc.edu
    Phone: 410-455-3021


    If you wish to submit a copyright complaint or withdrawal request, please email mdsoar-help@umd.edu.