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dc.contributor.advisorParente, Frederick
dc.contributor.authorMeads, Kristy L.
dc.contributor.departmentTowson University. Department of Psychologyen_US
dc.date.accessioned2020-03-10T20:33:15Z
dc.date.available2020-03-10T20:33:15Z
dc.date.issued2020-03-09
dc.date.submitted2019-05
dc.description(M.A.) -- Towson University, 2019en_US
dc.description.abstractSoman, an organophosphorus (OP) compound, disrupts nervous system function through inactivation of acetylcholinesterase (AChE), the enzyme that breaks down acetylcholine at synapses. Left untreated, a state of prolonged seizure activity (status epilepticus, SE) is induced, causing widespread neuronal damage and associated cognitive and behavioral impairments. Previous research demonstrated that therapeutic stimulation of A1 adenosine receptors (A1ARs) can prevent or terminate soman-induced seizure. Here, we examined the ability of three potent A1AR agonists to provide neuroprotection and, ultimately, prevent observable cognitive and behavioral deficits following exposure to soman. Sprague Dawley rats were challenged with a seizure-inducing dose of soman (1.2 x LD50) and treated 1 minute later with one of the following A1AR agonists: (6)-Cyclopentyladenosine (CPA), 2-Chloro-N6-cyclopentyladenosine (CCPA) or (±)-5'-Chloro-5'-deoxy-ENBA (cdENBA). An active avoidance shuttle box task was used to evaluate locomotor responses to aversive stimuli at 3, 7 and 14 days post exposure. Animals treated with CPA, CCPA or cdENBA demonstrated a higher number of avoidance responses and a faster reaction to the aversive stimulus than the soman/saline control group across all three sessions. Findings suggest that A1AR agonism is a promising neuroprotective countermeasure, capable of preventing the long-term deficits in learning and memory that are characteristic of soman intoxication.en_US
dc.description.urihttp://library.towson.edu/digital/collection/etd/id/72019en_US
dc.formatapplication/pdf
dc.format.extentix, 50 pagesen_US
dc.genrethesesen_US
dc.identifierdoi:10.13016/m2c5pv-pydu
dc.identifier.otherTSP2019Meads
dc.identifier.urihttp://hdl.handle.net/11603/17532
dc.language.isoen_USen_US
dc.relation.isAvailableAtTowson University
dc.titleEvaluation of candidate adenosine receptor agonists as neuroprotective countermeasures for soman intoxicationen_US
dc.typeTexten_US


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