Multiple Levels of Suffering: Discrimination in Health-Care Settings Is Associated With Enhanced Laboratory Pain Sensitivity in Sickle Cell Disease
Links to Fileshttps://journals.lww.com/clinicalpain/fulltext/2016/12000/Multiple_Levels_of_Suffering__Discrimination_in.8.aspx
MetadataShow full item record
Type of Work10 pages
journal articles postprints
Citation of Original PublicationMathur, V. A., Kiley, K. B., Haywood, C., Jr, Bediako, S. M., Lanzkron, S., Carroll, C. P., Buenaver, L. F., Pejsa, M., Edwards, R. R., Haythornthwaite, J. A., & Campbell, C. M. (2016). Multiple Levels of Suffering: Discrimination in Health-Care Settings is Associated With Enhanced Laboratory Pain Sensitivity in Sickle Cell Disease. The Clinical journal of pain, 32(12), 1076–1085. https://doi.org/10.1097/AJP.0000000000000361
RightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
Attribution-NonCommercial-NoDerivatives 4.0 International
This is not the final published version.
Access to this item will begin on 4/1/2017
Objective: People living with sickle cell disease (SCD) experience severe episodic and chronic pain and frequently report poor interpersonal treatment within health-care settings. In this particularly relevant context, we examined the relationship between perceived discrimination and both clinical and laboratory pain. Methods: Seventy-one individuals with SCD provided self-reports of experiences with discrimination in health-care settings and clinical pain severity, and completed a psychophysical pain testing battery in the laboratory. Results: Discrimination in health-care settings was correlated with greater clinical pain severity and enhanced sensitivity to multiple laboratory-induced pain measures, as well as stress, depression, and sleep. After controlling for relevant covariates, discrimination remained a significant predictor of mechanical temporal summation (a marker of central pain facilitation), but not clinical pain severity or suprathreshold heat pain response. Furthermore, a significant interaction between experience with discrimination and clinical pain severity was associated with mechanical temporal summation; increased experience with discrimination was associated with an increased correlation between clinical pain severity and temporal summation of pain. Discussion: Perceived discrimination within health-care settings was associated with pain facilitation. These findings suggest that discrimination may be related to increased central sensitization among SCD patients, and more broadly that health-care social environments may interact with pain pathophysiology.
The following license files are associated with this item:
- Creative Commons