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    The use of 3-nitropropionic acid to create a model of aging in mice

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    Ardinger Thesis (446.6Kb)
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    http://library.towson.edu/cdm/ref/collection/etd/id/47953
    Permanent Link
    http://hdl.handle.net/11603/3101
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    • Towson University Graduate Theses and Dissertations
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    Author/Creator
    Ardinger, Cherish
    Date
    2016-08-08
    2016-05
    Type of Work
    application/pdf
    vii, 44 pages
    Text
    theses
    Department
    Towson University. Department of Psychology
    Abstract
    This experiment was designed to create an aging model in mice that is more cost-effective, time-efficient, and easier for the animals to recover from than traditional models. This model was designed using intraperitoneal (IP) injections of 3-nitropropionic acid (3NP), a mitochondrial toxin that is known to damage the striatum. The striatum has been shown in previous literature to play a large role in the aging process. This experiment compared two cumulative doses of 3NP: 540 mg/kg, 720 mg/kg, and a saline control. The 540 mg/kg dose was given at either a steady dose every other day or an increasing dose given twice a day. These dosing schedules were both compared to one another and control mice to assess which was the most effective at creating cognitive and motor deficits when mice receiving these respective treatments were tested on the Stone T-Maze (STM) and rotarod. It was found that an escalating dose of 3NP impaired retention in the STM and motor function on the rotarod task.


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    Towson University
    8000 York Road
    Towson, Maryland 21252

    Website:
    www.towson.edu

    Contact Info:
    azukowski@towson.edu
    410-704-5318
    http://libraries.towson.edu/md-soar


    If you wish to submit a copyright complaint or withdrawal request, please email mdsoar-help@umd.edu.