UMBC Chemical, Biochemical & Environmental Engineering Department
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Faculty in our department focus their research in nine core areas encompassing biological, environmental, and educational research. Our department offers an undergraduate course of study leading to a B.S. in Chemical Engineering through three tracks of study: (i) Traditional Track, (ii) Biotechnology and Bioengineering Track and (iii) Environmental Engineering and Sustainability track. We also offer both M.S. and Ph.D. degrees through two different graduate programs. Details can be found on our website: http://www.umbc.edu/cbe
Recent Submissions
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Developments in Insulin Manufacturing Using Cell-Free Systems
The primary aim of this method is to emulate the naturally occurring mechanisms which take place in vivo, when converting preproinsulin into metabolically active insulin (4). Figure 2, displays the binding of pre-proinsulin ... -
Mechanoregulation of T-cell Function through Yap
Although tumor immunotherapy has been developed for various cancers, sustaining T-cell activation and recruitment in immunosuppressive solid tumors remains a major hurdle. T-cell function is modulated by mechanical cues, ... -
Synthetic yeast brews neuroactive compounds
(Nature, 2020-10-28)Metabolic engineering offers the flexibility to meet market demand for bioactive natural products but can be hampered when a necessary protein or intermediate is toxic. In yeast, modifying the subcellular localization of ... -
American Chemical Society honors UMBC’s Lee Blaney for commitment to mentoring student researchers
(UMBC News, 2020-10-28) -
Characterization of Met25 as a color associated genetic marker in Yarrowia lipolytica
(Elsevier, 2020-10-03)Yarrowia lipolytica offers an ideal host for biosynthesis of high value natural products and oleochemicals through metabolic engineering despite being restricted to a limited number of selective markers, and counter-selection ... -
Thermo in the Time of COVID-19: Using Improvisation to Foster Discussion and Translating the Experience to Online Learning
(Springer Nature, 2020-09-02)This paper covers teaching a graduate thermodynamics class as a seminar and using improvisational activities to foster community and discussion. The paper includes the experience of piloting improvisational activities ... -
Pavement alters delivery of sediment and fallout radionuclides to urban streams
(Elsevier, 2020-03-16)Sediment from urban impervious surfaces has the potential to be an important vector for contaminants, particularly where stormwater culverts and other buried channels draining large impervious areas exit from underground ... -
Intratumoral generation of photothermal gold nanoparticles through a vectorized biomineralization of ionic gold
(Springer Nature, 2020-09-10)Various cancer cells have been demonstrated to have the capacity to form plasmonic gold nanoparticles when chloroauric acid is introduced to their cellular microenvironment. But their biomedical applications are limited, ... -
Competitive Adsorption of As (III), As (V), and PO 4 by an Iron Oxide Impregnated Activated Carbon: Surface Complex Modeling
(Springer Nature, 2020-09-02)The objective of this study was to predict the competitive adsorption of As(III), As(V), and PO₄ by an iron oxide impregnated carbon (L-Act, 9% Fe(III) amorphous iron oxide) over a range of environmental conditions using ... -
Design and measurements of n for the multicomponent semiconductor
(SPIE, 2020-08-20)A great deal of research has been performed on refractive index n and extinction coefficient k due to varieties of applications in optical industries. The dispersion equation is described for the photons of varying energies ... -
Comprehensive Analysis of Aspergillus nidulans PKA Phosphorylome Identifies a Novel Mode of CreA Regulation
(American Society for Microbiology, 2019-04)The fungal cell-wall integrity signaling (CWIS) pathway regulates cellular response to environmental stress to enable wall repair and resumption of normal growth. This complex, interconnected, pathway has been only partially ... -
Dynamic transcriptomic and phosphoproteomic analysis during cell wall stress in Aspergillus nidulans
(ASBMB Publications, 2020-08-01)The fungal cell-wall integrity signaling (CWIS) pathway regulates cellular response to environmental stress to enable wall repair and resumption of normal growth. This complex, interconnected, pathway has been only partially ... -
The Aspergillus fumigatus Phosphoproteome Reveals Roles of High-Osmolarity Glycerol Mitogen-Activated Protein Kinases in Promoting Cell Wall Damage and Caspofungin Tolerance
(American Society for Microbiology, 2020-02-04)The filamentous fungus Aspergillus fumigatus can cause a distinct set of clinical disorders in humans. Invasive aspergillosis (IA) is the most common life-threatening fungal disease of immunocompromised humans. The ... -
Impact of Four Common Hydrogels on Amyloid-β (Aβ) Aggregation and Cytotoxicity: Implications for 3D Models of Alzheimer’s Disease
(ACS Publications, 2020-08-06)The physiochemical properties of hydrogels utilized in 3D culture can be used to modulate cell phenotype and morphology with a striking resemblance to cellular processes that occur in vivo. Indeed, research areas including ... -
Direct Real Time Detection of Adenosine Triphosphate Release from Astrocytes in Three Dimensional Culture Using an Integrated Electrochemical Aptamer Based Sensor
(ACS Publications, 2019-02-12)In this manuscript, we describe the development and application of electrochemical aptamer-based (E-AB) sensors directly interfaced with astrocytes in three-dimensional (3D) cell culture to monitor stimulated release of ... -
Collagen hydrogel confinement of Amyloid-β (Aβ) accelerates aggregation and reduces cytotoxic effects
(Elsevier, 2020-05-25)Alzheimer's disease (AD) is the most common form of dementia and is associated with the accumulation of amyloid-β (Aβ), a peptide whose aggregation has been associated with neurotoxicity. Drugs targeting Aβ have shown great ... -
Protein folding and assembly in confined environments: Implications for protein aggregation in hydrogels and tissues
(Elsevier, 2020-06-06)In the biological milieu of a cell, soluble crowding molecules and rigid confined environments strongly influence whether the protein is properly folded, intrinsically disordered proteins assemble into distinct phases, or ... -
Discovery of treatment for nerve agents targeting a new metabolic pathway
(Springer Nature Switzerland AG., 2020-07-27)The inhibition of acetylcholinesterase is regarded as the primary toxic mechanism of action for chemical warfare agents. Recently, there have been numerous reports suggesting that metabolic processes could significantly ... -
Analytical solution for a hybrid Logistic‐Monod cell growth model in batch and continuous stirred tank reactor culture
(Wiley, 2019-11-23)Monod and Logistic growth models have been widely used as basic equations to describe cell growth in bioprocess engineering. In the case of the Monod equation, the specific growth rate is governed by a limiting nutrient, ... -
Branch point control at malonyl-CoA node: A computational framework to uncover the design principles of an ideal genetic-metabolic switch
(Elsevier, 2020-04-24)Living organism is an intelligent system coded by hierarchically-organized information to perform precisely-controlled biological functions. Biophysical models are important tools to uncover the design rules underlying ...
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