UMBC Chemical, Biochemical & Environmental Engineering Department
Browse by
Faculty in our department focus their research in nine core areas encompassing biological, environmental, and educational research. Our department offers an undergraduate course of study leading to a B.S. in Chemical Engineering through three tracks of study: (i) Traditional Track, (ii) Biotechnology and Bioengineering Track and (iii) Environmental Engineering and Sustainability track. We also offer both M.S. and Ph.D. degrees through two different graduate programs. Details can be found on our website: http://www.umbc.edu/cbe
Recent Submissions
-
Comprehensive Analysis of Aspergillus nidulans PKA Phosphorylome Identifies a Novel Mode of CreA Regulation
(American Society for Microbiology, 2019-04)The fungal cell-wall integrity signaling (CWIS) pathway regulates cellular response to environmental stress to enable wall repair and resumption of normal growth. This complex, interconnected, pathway has been only partially ... -
Dynamic transcriptomic and phosphoproteomic analysis during cell wall stress in Aspergillus nidulans
(ASBMB Publications, 2020-08-01)The fungal cell-wall integrity signaling (CWIS) pathway regulates cellular response to environmental stress to enable wall repair and resumption of normal growth. This complex, interconnected, pathway has been only partially ... -
The Aspergillus fumigatus Phosphoproteome Reveals Roles of High-Osmolarity Glycerol Mitogen-Activated Protein Kinases in Promoting Cell Wall Damage and Caspofungin Tolerance
(American Society for Microbiology, 2020-02-04)The filamentous fungus Aspergillus fumigatus can cause a distinct set of clinical disorders in humans. Invasive aspergillosis (IA) is the most common life-threatening fungal disease of immunocompromised humans. The ... -
Impact of Four Common Hydrogels on Amyloid-β (Aβ) Aggregation and Cytotoxicity: Implications for 3D Models of Alzheimer’s Disease
(ACS Publications, 2020-08-06)The physiochemical properties of hydrogels utilized in 3D culture can be used to modulate cell phenotype and morphology with a striking resemblance to cellular processes that occur in vivo. Indeed, research areas including ... -
Direct Real Time Detection of Adenosine Triphosphate Release from Astrocytes in Three Dimensional Culture Using an Integrated Electrochemical Aptamer Based Sensor
(ACS Publications, 2019-02-12)In this manuscript, we describe the development and application of electrochemical aptamer-based (E-AB) sensors directly interfaced with astrocytes in three-dimensional (3D) cell culture to monitor stimulated release of ... -
Collagen hydrogel confinement of Amyloid-β (Aβ) accelerates aggregation and reduces cytotoxic effects
(Elsevier, 2020-05-25)Alzheimer's disease (AD) is the most common form of dementia and is associated with the accumulation of amyloid-β (Aβ), a peptide whose aggregation has been associated with neurotoxicity. Drugs targeting Aβ have shown great ... -
Protein folding and assembly in confined environments: Implications for protein aggregation in hydrogels and tissues
(Elsevier, 2020-06-06)In the biological milieu of a cell, soluble crowding molecules and rigid confined environments strongly influence whether the protein is properly folded, intrinsically disordered proteins assemble into distinct phases, or ... -
Discovery of treatment for nerve agents targeting a new metabolic pathway
(Springer Nature Switzerland AG., 2020-07-27)The inhibition of acetylcholinesterase is regarded as the primary toxic mechanism of action for chemical warfare agents. Recently, there have been numerous reports suggesting that metabolic processes could significantly ... -
Analytical solution for a hybrid Logistic‐Monod cell growth model in batch and continuous stirred tank reactor culture
(Wiley, 2019-11-23)Monod and Logistic growth models have been widely used as basic equations to describe cell growth in bioprocess engineering. In the case of the Monod equation, the specific growth rate is governed by a limiting nutrient, ... -
Branch point control at malonyl-CoA node: A computational framework to uncover the design principles of an ideal genetic-metabolic switch
(Elsevier, 2020-04-24)Living organism is an intelligent system coded by hierarchically-organized information to perform precisely-controlled biological functions. Biophysical models are important tools to uncover the design rules underlying ... -
Debottlenecking mevalonate pathway for antimalarial drug precursor amorphadiene biosynthesis in Yarrowia lipolytica
(Elsevier, 2020-01-02)World Health Organization reports that half of the population in developing countries are at risk of malaria infection. Artemisinin, the most potent anti-malaria drug, is a sesquiterpene endoperoxide extracted from the ... -
Refactoring Ehrlich Pathway for High-Yield 2-Phenylethanol Production in Yarrowia lipolytica
(ACS Publications, 2020-03-05)Efficient microbial synthesis of chemicals requires the coordinated supply of precursors and cofactors to maintain cell growth and product formation. Substrates with different entry points into the metabolic network have ... -
Coupling metabolic addiction with negative autoregulation to improve strain stability and pathway yield
(Elsevier, 2020-05-20)Metabolic addiction, an organism that is metabolically addicted with a compound to maintain its growth fitness, is an underexplored area in metabolic engineering. Microbes with heavily engineered pathways or genetic circuits ... -
CRISPR-Cas12a/Cpf1-assisted precise, efficient and multiplexed genome-editing in Yarrowia lipolytica
(Elsevier, 2019-11-22)CRISPR-Cas9 has been widely adopted as the basic toolkit for precise genome-editing and engineering in various organisms. Alternative to Cas9, Cas12 or Cpf1 uses a simple crRNA as a guide and expands the protospacer adjacent ... -
Unstructured kinetic models to simulate an arabinose switch that decouples cell growth from metabolite production
(Elsevier, 2020-07-14)Modeling synthetic gene circuits to implement dynamic flux balancing is crucial in teaching and exploring metabolic engineering strategies to repartition metabolic precursors and construct efficient microbial cell factories. ... -
Engineering Yarrowia lipolytica as a Chassis for De Novo Synthesis of Five Aromatic-Derived Natural Products and Chemicals
(ACS Publications, 2020-07-10)Yarrowia lipolytica is a novel microbial chassis to upgrade renewable low-cost carbon feedstocks to high-value commodity chemicals and natural products. In this work, we systematically characterized and removed the ... -
Genetic and bioprocess engineering to improve squalene production in Yarrowia lipolytica
(Elsevier, 2020-08-10)Squalene is the precursor for triterpene-based natural products and steroids-based drugs. It has been widely used as pharmaceutical intermediates and personal care products. The aim of this work is to test the feasibility ... -
A roadmap to engineering antiviral natural products synthesis in microbe
(Elsevier, 2020-08-12)Natural products continue to be the inspirations for us to discover and acquire new drugs. The seemingly unstoppable viruses have kept records high to threaten human health and well-being. The diversity and complexity of ... -
Robust and easy macrofluidic connections in acrylic
(Royal Society of Chemistry, 2012-04-23) -
The optimization of Naringenin biosynthesis pathway using Yarrowia lipolitica cell culture
(Kharazmi University, 2020-06-30)Yarrowia lipolytica, as a good cell factory to speed up the production of plant pharmaceutical components, has been considered to be one of the most important and attractive micro-organisms in recent years, due to its high ...
RSS 1.0