UMBC Chemical, Biochemical & Environmental Engineering Department
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Faculty in our department focus their research in nine core areas encompassing biological, environmental, and educational research. Our department offers an undergraduate course of study leading to a B.S. in Chemical Engineering through three tracks of study: (i) Traditional Track, (ii) Biotechnology and Bioengineering Track and (iii) Environmental Engineering and Sustainability track. We also offer both M.S. and Ph.D. degrees through two different graduate programs. Details can be found on our website: http://www.umbc.edu/cbe
Recent Submissions
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Fluorescence Measurement of Pericellular Oxygen
(Elsevier Inc., 2016-02-16)Under normal physiological conditions, the mitochondrial electron transport chain consumes cellular/mitochondrial oxygen (O₂) to generate a proton motive force (ΔΨm) which powers ATP synthesis. Thus, many cellular processes ... -
Neuron absorption study and mid-IR optical excitations
(SPIE, 2012-02-09)Neuronal optical excitation can provide non-contacting tools to explore brain circuitry and a durable stimulation interface for cardiac pacing and visual as well as auditory sensory neuronal stimulation. To obtain accurate ... -
Biocompatible hydrogel membranes for the protection of RNA aptamer-based electrochemical sensors
(SPIE, 2013-05-31)Electrochemical-aptamer based (E-AB) sensors represent a universal specific, selective, and sensitive sensing platform for the detection of small molecule targets. Their specific detection abilities are afforded by ... -
Altered structural and mechanical properties in decellularized rabbit carotid arteries
(Elsevier B.V, 2008-12-11)Recently, major achievements in creating decellularized whole tissue scaffolds have drawn considerable attention to decellularization as a promising approach for tissue engineering. Decellularized tissues are expected ... -
β1-Integrin cytoskeletal signaling regulates sensory neuron response to matrix dimensionality
(Elsevier B.V, 2013-09-17)Neuronal differentiation, pathfinding and morphology are directed by biochemical cues that in vivo are presented in a complex scaffold of extracellular matrix (ECM). This microenvironment is three-dimensional (3D) and ... -
Spatially monitoring oxygen level in 3D microfabricated cell culture systems using optical oxygen sensing beads
(Royal Society of Chemistry, 2013-04-21)Capability of measuring and monitoring local oxygen concentration at the single cell level (tens of microns scale) is often desirable but difficult to achieve in cell culture. In this study, biocompatible oxygen sensing ... -
Solute diffusion and interactions in cross-linked poly(ethylene glycol) hydrogels studied by Fluorescence Correlation Spectroscopy
(Royal Society of Chemistry, 2010-06-07)Controlled diffusion and release of soluble molecules is one of the key challenges in developing three-dimensional (3D) scaffolds for tissue engineering and drug delivery applications in part because current methods to ... -
Influence of cell-adhesive peptide ligands on poly(ethylene glycol) hydrogel physical, mechanical and transport properties
(Elsevier B.V, 2010-04-10)Synthetic three-dimensional (3D) scaffolds for cell and tissue engineering routinely utilize peptide ligands to provide sites for cell adhesion and to promote cellular activity. Given the fact that recent studies have ... -
Hydrolytically degradable poly(ethylene glycol) hydrogel scaffolds as a cell delivery vehicle: Characterization of PC12 cell response
(Wiley Periodicals, 2013-06-22)The central nervous system (CNS) has a low intrinsic potential for regeneration following injury and disease, yet neural stem/progenitor cell (NPC) transplants show promise to provide a dynamic therapeutic in this complex ... -
Fluorescent silica particles for monitoring oxygen levels in three‐dimensional heterogeneous cellular structures
(Wiley Periodicals, 2012-04-17)Bacterial biofilms are a major obstacle challenging the development of more effective therapies to treat implant infections. Oxygen availability to bacterial cells has been implicated in biofilm formation and planktonic ... -
Fluorescent microparticles for sensing cell microenvironment oxygen levels within 3D scaffolds
(Elsevier B.V, 2009-03-14)We present the development and characterization of fluorescent oxygen-sensing microparticles designed for measuring oxygen concentration in microenvironments existing within standard cell culture and transparent three-dimensional ... -
Fabrication of a layered microstructured polycaprolactone construct for 3-D tissue engineering
(Taylor and Francis Online, 2012-04-02)Successful artificial tissue scaffolds support regeneration by promoting cellular organization as well as appropriate mechanical and biological functionality. We have previously shown in vitro that 2-D substrates with ... -
Characterization of protein release from hydrolytically degradable poly(ethylene glycol) hydrogels
(Wiley Periodicals, 2010-08-27)We present a novel fully hydrophilic, hydrolytically degradable poly(ethylene glycol) (PEG) hydrogel suitable for soft tissue engineering and delivery of protein drugs. The gels were designed to overcome drawbacks associated ... -
Three-Dimensional Environment Sustains Morphological Heterogeneity and Promotes Phenotypic Progression During Astrocyte Development
(Mary Ann Liebert, Inc, 2016-06-01)Astrocytes are critical for coordinating normal brain function by regulating brain metabolic homeostasis, synaptogenesis and neurotransmission, and blood–brain barrier permeability and maintenance. Dysregulation of normal ... -
Substrate Three-Dimensionality Induces Elemental Morphological Transformation of Sensory Neurons on a Physiologic Timescale
(Mary Ann Liebert, Inc, 2011-09-08)The natural environment of a neuron is the three-dimensional (3D) tissue. In vivo, embryonic sensory neurons transiently express a bipolar morphology with two opposing neurites before undergoing cytoplasmic and cytoskeletal ... -
Protein–Hydrogel Interactions in Tissue Engineering: Mechanisms and Applications
(Mary Ann Liebert, Inc, 2012-11-13)Recent advances in our understanding of the sophistication of the cellular microenvironment and the dynamics of tissue remodeling during development, disease, and regeneration have increased our appreciation of the current ... -
Enhancement of human neural stem cell self‐renewal in 3D hypoxic culture
(Wiley Periodicals, 2016-11-21)The pathology of neurological disorders is associated with the loss of neuronal and glial cells that results in functional impairments. Human neural stem cells (hNSCs), due to their self-renewing and multipotent characteristics, ... -
Synthesis and Characterization of Carboxymethylcellulose-Methacrylate Hydrogel Cell Scaffolds
(MDPI, 2010-08-26)Many carbohydrates pose advantages for tissue engineering applications due to their hydrophilicity, degradability, and availability of chemical groups for modification. For example, carboxymethylcellulose (CMC) is a ... -
Bridging the divide between neuroprosthetic design, tissue engineering and neurobiology
(Frontiers Media S.A., 2010-02-08)Neuroprosthetic devices have made a major impact in the treatment of a variety of disorders such as paralysis and stroke. However, a major impediment in the advancement of this technology is the challenge of maintaining ...
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