Recent Submissions

  • Modeling Atmosphere-Ocean Radiative Transfer: A PACE Mission Perspective 

    Chowdhary, Jacek; Zhai, Peng-Wang; Boss, Emmanuel; Dierssen, Heidi M.; Frouin, Robert; Ibrahim, Amir; Lee, Zhongping; Remer, Lorraine Ann; Twardowski, Michael; Xu, Feng; Zhang, Xiaodong; Ottaviani, Matteo; Espinosa, William Reed; Ramon, Didier (Frontiers Media S.A, 2019-06-18)
    The research frontiers of radiative transfer (RT) in coupled atmosphere-ocean systems are explored to enable new science and specifically to support the upcoming Plankton, Aerosol, Cloud ocean Ecosystem (PACE) satellite ...
  • Stochastic Binary Opinion Model 

    Stamoulas, Serap Tay; Rathinam, Muruhan (2019-02-06)
    We study a stochastic binary opinion model where agents in a group are considered to hold an opinion of 0 or 1 at each moment. An agent in the group updates his/her opinion based on the group's opinion configuration and ...
  • A Unified Approach for Solving Sequential Selection Problems 

    Goldenshluger, Alexander; Malinovsky, Yaakov; Zeevi, Assaf (2019-05-27)
    In this paper we develop a unified approach for solving a wide class of sequential selection problems. This class includes, but is not limited to, selection problems with no-information, rank-dependent rewards, and considers ...
  • The Crystal Structure of Klebsiella pneumoniae FeoA Reveals a Site For Protein-Protein Interactions 

    Linkous, Richard O.; Sestok, Alexandrea E.; Smith, Aaron T. (2019-01-08)
    In order to establish infection, pathogenic bacteria must obtain essential nutrients such as iron. Under acidic and/or anaerobic conditions, most bacteria utilize the Feo system in order to acquire ferrous iron (Fe²⁺) from ...
  • Intercomparison of Mixing Layer Heights from the National Weather Service Ceilometer Test Sites and Collocated Radiosondes 

    Hicks, Micheal; Demoz, Belay; Vermeesch, Kevin; Atkinson, Dennis (American Meteorological Society, 2019-01-21)
    A network of automated weather stations (AWS) with ceilometers can be used to detect sky conditions, aerosol dispersion, and mixing layer heights, in addition to the routine surface meteorological parameters (temperature, ...
  • Replicating Meyerhoff for inclusive excellence in STEM 

    Domingo, Mariano R. Sto.; Sharp, Starlette; Freeman, Amy; Freeman Jr., Thomas; Freeman, Thomas, Jr.; Harmon, Keith; Wiggs, Mitsue; Sathy, Viji; Panter, Abigail T.; Oseguera, Leticia; Sun, Shuyan; Williams, Mary Elizabeth; Templeton, Joseph; Folt, Carol L.; Barron, Eric J.; Hrabowski III, Freeman A.; Maton, Kenneth I.; Crimmins, Michael; Fisher, Charles R.; Summers, Michael F. (American Association for the Advancement of Science, 2019-04-26)
  • The true nature of Swift J0746.3-1608: a possible Intermediate Polar showing accretion state changes 

    Bernardini, F.; de Martino, D.; Mukai, K.; Falanga, M. (2018-12-21)
    Optical and X-ray observations suggested that the 9.38 h binary, SWIFT J0746.3- 1608 could be a Cataclysmic Variable of the magnetic or nova-like type, or a low mass X-ray binary. Its optical, UV, and X-ray light curves ...
  • The small and large ribosomal subunits depend on each other for stability and accumulation 

    Gregory, Brian; Rahman, Nusrat; Bommakanti, Ananth; Shamsuzzaman, Md; Thapa, Mamata; Lescure, Alana; Zengel, Janice M.; Lindahl, Lasse (Life Science Alliance, 2019-03-05)
    The 1:1 balance between the numbers of large and small ribosomal subunits can be disturbed by mutations that inhibit the assembly of only one of the subunits. Here, we have investigated if the cell can counteract an imbalance ...
  • Analysis of cell cycle parameters during the transition from unhindered growth to ribosomal and translational stress conditions 

    Shamsuzzaman, Md; Bommakanti, Ananth; Zapinsky, Aviva; Rahman, Nusrat; Pascual, Clarence; Lindahl, Lasse (PLOS, 2017-10-13)
    Abrogation of ribosome synthesis (ribosomal stress) leads to cell cycle arrest. However, the immediate cell response to cessation of ribosome formation and the transition from normal cell proliferation to cell cycle arrest ...
  • The Ribosomal Protein uL22 Modulates the Shape of the Protein Exit Tunnel 

    Wekselman, Itai; Zimmerman, Ella; Davidovich, Chen; Lindahl, Lasse; Zengel, Janice M.; Yonath, Ada (Cell Press, 2017-08-01)
    Erythromycin is a clinically useful antibiotic that binds to an rRNA pocket in the ribosomal exit tunnel. Commonly, resistance to erythromycin is acquired by alterations of rRNA nucleotides that interact with the drug. ...
  • The extended loops of ribosomal proteins uL4 and uL22 of Escherichia coli contribute to ribosome assembly and protein translation 

    Lawrence, Marlon G.; Shamsuzzaman, M.d.; Kondopaka, Maithri; Pascual, Clarence; Zengel, Janice M.; Lindahl, Lasse (Oxford University Press, 2016-06-01)
    Nearly half of ribosomal proteins are composed of a domain on the ribosome surface and a loop or extension that penetrates into the organelle's RNA core. Our previous work showed that ribosomes lacking the loops of ribosomal ...
  • A new system for naming ribosomal proteins 

    Ban, Nenad; Beckmann, Roland; Cate, Jamie H.D.; Dinman, Jonathan D.; Dragon, François; Ellis, Steven R.; Lafontaine, Denis L.J.; Lindahl, Lasse; Liljas, Anders; Lipton, Jeffrey M.; McAlear, Michael A.; Moore, Peter B.; Noller, Harry F.; Ortega, Joaquin; Panse, Vikram Govind; Ramakrishnan, V.; Spahn, Christian M.T.; Steitz, Thomas A.; Tchorzewski, Marek; Tollervey, David; Warren, Alan J.; Williamson, James R.; Wilson, Daniel; Yonath, Ada; Yusupov, Marat (Elsevier Ltd, 2014-02-10)
    A system for naming ribosomal proteins is described that the authors intend to use in the future. They urge others to adopt it. The objective is to eliminate the confusion caused by the assignment of identical names to ...
  • Repressed synthesis of ribosomal proteins generates protein-specific cell cycle and morphological phenotypes 

    Thapa, Mamata; Bommakanti, Ananth; Shamsuzzaman, Md.; Gregory, Brian; Samsel, Leigh; Zengel, Janice M.; Lindahl, Lasse (American Society for Cell Biology, 2013-10-09)
    The biogenesis of ribosomes is coordinated with cell growth and proliferation. Distortion of the coordinated synthesis of ribosomal components affects not only ribosome formation, but also cell fate. However, the connection ...
  • RNase MRP is required for entry of 35S precursor rRNA into the canonical processing pathway 

    Lindahl, Lasse; Bommankanti, Ananth; Li, Xing; Hayden, Lauren; Jones, Adrienne; Khan, Miriam; Oni, Tolulope; Zengel, Janice M. (The RNA Society, 2009-07)
    RNase MRP is a nucleolar RNA–protein enzyme that participates in the processing of rRNA during ribosome biogenesis. Previous experiments suggested that RNase MRP makes a nonessential cleavage in the first internal transcribed ...
  • Comparative studies on translation arrest in the CrbCmlA and SecM Peptides 

    Lawrence, Marlon G.; Lindahl, Lasse; Zengel, Janice M. (American Society for Microbiology, 2008-06-27)
    Amino acids are polymerized into peptides in the peptidyl transferase center of the ribosome. The nascent peptides then pass through the exit tunnel before they reach the extraribosomal environment. A number of nascent ...
  • Mutation from guanine to adenine in 25S rRNA at the position equivalent to E. coli A2058 does not confer erythromycin sensitivity in Sacchromyces cerevisae 

    Bommakanti, Ananth S.; Lindahl, Lasse; Zengel, Janice M. (The RNA Society, 2008-03)
    The macrolide erythromycin binds to the large subunit of the prokaryotic ribosome near the peptidyltransferase center (PTC) and inhibits elongation of new peptide chains beyond a few amino acids. Nucleotides A2058 and ...
  • Regulation of Ribosomal Protein Synthesis in Vibrio cholerae 

    Allen, Todd D.; Watkins, Tonya; Lindahl, Lasse; Zengel, Janice M. (American Society for Microbiology, 2004-09)
    We have investigated the regulation of the S10 and spc ribosomal protein (r-protein) operons in Vibrio cholerae. Both operons are under autogenous control; they are mediated by r-proteins L4 and S8, respectively. Our results ...
  • Identification of a functional core in the RNA component of RNase MRP of budding yeasts 

    Li, Xing; Zaman, Sephorah; Langdon, Yvette; Zengel, Janice M.; Lindahl, Lasse (Oxford University Press, 2004-07-14)
    RNase MRP is an endonuclease participating in ribosomal RNA processing. It consists of one RNA and at least nine protein subunits. Using oligonucleotide-directed mutagenesis, we analyzed the functional role of five of the ...
  • The extended loops of ribosomal proteins L4 and L22 are not required for ribosome assembly or L4-mediated autogenous control 

    Zengel, Janice M.; Jerauld,  Adam; Walker,  Andre; Wahl,  Markus C.; Lindahl,  Lasse (The RNA Society, 2003-10)
    Ribosomal proteins L4 and L22 both have a globular domain that sits on the surface of the large ribosomal subunit and an extended loop that penetrates its core. The tips of both loops contribute to the lining of the peptide ...
  • RNA-structural Mimicry in Escherichia coli Ribosomal Protein L4-dependent Regulation of the S10 Operon 

    Stelzl, Ulrich; Zengel, Janice M.; Tovbina, Marina; Walker, Marquis; Nierhaus, Knud H.; Lindahl, Lasse; Patel, Dinshaw J. (American Society for Biochemistry and Molecular Biology, 2003-07-25)
    Ribosomal protein L4 regulates the 11-gene S10 operon in Escherichia coli by acting, in concert with transcription factor NusA, to cause premature transcription termination at a Rho-independent termination site in the ...

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