UMBC College of Natural and Mathematical Sciences
Browse by
Collections in this community
Recent Submissions
-
Efficient methods for the estimation of the multinomial parameter for the two-trait group testing model
(2018)Estimation of a single Bernoulli parameter using pooled sampling is among the oldest problems in the group testing literature. To carry out such estimation, an array of efficient estimators have been introduced covering a ... -
Spatial alterations of De Novo purine biosynthetic enzymes by Akt-independent PDK1 signaling pathways
(PLOS ONE, 2018)A macromolecular complex of the enzymes involved in human de novo purine biosynthesis, the purinosome, has been shown to consist of a core assembly to regulate the metabolic activity of the pathway. However, it remains ... -
LIDAR PROFILING IN THE LOWER TROPOSPHERE: EXPERIENCE FROM PECAN
(EPJ, 2018)Results from the PECAN (Plains Elevated Convection at Night) campaign are discussed. In particular, the utility of simple backscatter lidars/ceilometers in quantifying atmospheric dynamics parameters and variables as well ... -
MIXED LAYER DEPTHS VIA DOPPLER LIDAR DURING LOW-LEVEL JET EVENTS
(EPJ, 2018)A low-level jet (LLJ) is a prominent wind speed peak in the lower troposphere. Nocturnal LLJs have been shown to transport and mix atmospheric constituents from the residual layer down to the surface, breaching quiescent ... -
The role of the C-domain of bacteriophage T4 gene 32 protein in ssDNA binding and dsDNA helix-destabilization: Kinetic, single-molecule, and cross-linking studies
(PLOS ONE, 2018)The model single-stranded DNA binding protein of bacteriophage T4, gene 32 protein (gp32) has well-established roles in DNA replication, recombination, and repair. gp32 is a single-chain polypeptide consisting of three ... -
Myeloid Derived-Suppressor Cells: Their role in cancer and obesity
(Elsevier, 2018-04)Myeloid-derived suppressor cells (MDSC) are present in most individuals with cancer where they inhibit adaptive and innate antitumor immunity and are an obstacle to cancer immunotherapies. Chronic inflammation is ... -
High fat diet and leptin promote tumor progression by inducing myeloid-derived suppressor cells
(Wiley, 2018)Obesity is a risk factor for cancer incidence and cancer mortality. The association of obesity and cancer is attributed to multiple factors, but the tightest linkage is with the chronic, low‐grade inflammation that accompanies ... -
CD3xPDL1 bi-specific T cell engager (BiTE) simultaneously activates T cells and NKT cells, kills PDL1⁺ tumor cells, and extends the survival of tumor-bearing humanized mice
(Oncotarget, 2017)Bi-specific T cell engagers (BiTEs) activate T cells through CD3 and target activated T cells to tumor-expressed antigens. BiTEs have shown therapeutic efficacy in patients with liquid tumors; however, they do not benefit ... -
Retrieval of aerosol properties and water-leaving reflectance from multi-angular polarimetric measurements over coastal waters
(The Optical Society, 2018)Ocean color remote sensing is an important tool to monitor water quality and biogeochemical conditions of ocean. Atmospheric correction, which obtains water-leaving radiance from the total radiance measured by satellite-borne ... -
Soluble CD80 Protein Delays Tumor Growth and Promotes Tumor-Infiltrating Lymphocytes
(American Association of Cancer Research, 2018-01)Tumor cells use various immune-suppressive strategies to overcome antitumor immunity. One such method is tumor expression of programmed death ligand-1 (PD-L1), which triggers apoptotic death or anergy upon binding programmed ... -
Minimal dissipation in processes far from equilibrium
(2018)central goal of thermodynamics is to identify optimal processes during which the least amount of energy is dissipated into the environment. Generally, even for simple systems, such as the parametric harmonic oscillator, ... -
MULTIGRID PRECONDITIONERS FOR THE NEWTON-KRYLOV METHOD IN THE OPTIMAL CONTROL OF THE STATIONARY NAVIER-STOKES EQUATIONS
(2018)In this work we construct multigrid preconditioners to be used in the Newton-Krylov method for a distributed optimal control problem constrained by the stationary Navier-Stokes equations. These preconditioners are shown ... -
ATP and Odor Mixture Activate TRPM5-Expressing Microvillous Cells and Potentially Induce Acetylcholine Release to Enhance Supporting Cell Endocytosis in Mouse Main Olfactory Epithelium
(Frontier, 2018)The main olfactory epithelium (MOE) functions to detect odor molecules, provide an epithelial surface barrier, and remove xenobiotics from inhaled air. Mechanisms coordinating the activities of different cell types within ... -
Carrier Dynamics, Optical Gain, and Lasing with Colloidal Quantum Wells
(ACS Publicaions, 2018)The most recent class of semiconductor nanocrystal to be synthesized colloidally is the quantum well, in which carriers are confined quantum mechanically in only one dimension. Electrons and holes in colloidal quantum wells ... -
Profiles of Emergent Writing Skills Among Preschool Children
(Springer, 2018)Background Research suggests that considerable individual differences may exist among preschool children in terms of emergent writing performance. However, there is no study examining this variability. Objective ... -
In vitro and in vivo characterization of three Cellvibrio japonicus glycoside hydrolase family 5 members reveals potent xyloglucan backbone-cleaving functions
(BioMed Central, 2018)Background Xyloglucan (XyG) is a ubiquitous and fundamental polysaccharide of plant cell walls. Due to its structural complexity, XyG requires a combination of backbone-cleaving and sidechain-debranching enzymes for ... -
Systems analysis of the Glycoside Hydrolase family 18 enzymes from Cellvibrio japonicus characterizes essential chitin degradation functions
(Journal of Biological Chemistry, 2018)Understanding the strategies used by bacteria to degrade polysaccharides constitutes an invaluable tool for biotechnological applications. Bacteria are major mediators of polysaccharide degradation in nature, however the ... -
A Mathematical Model for Enzyme Clustering in Glucose Metabolism
(Nature, 2017)We have recently demonstrated that the rate-limiting enzymes in human glucose metabolism organize into cytoplasmic clusters to form a multienzyme complex, the glucosome, in at least three different sizes. Quantitative ... -
On the Nature of the High-Energy Rollover in 1H 0419-577
(Oxford Academic, 2018)A NuSTAR/Swift observation of the luminous Seyfert 1 galaxy 1H 0419-577 taken during 2015 reveals one of the most extreme high energy cut-offs observed to date from an AGN - an origin due to thermal Comptonization would ... -
Chromatin Immunoprecipitation (ChIP) of Histone Modifications from Saccharomyces cerevisiae
(Jove, 2017)Histone post-translational modifications (PTMs), such as acetylation, methylation and phosphorylation, are dynamically regulated by a series of enzymes that add or remove these marks in response to signals received by the ...
RSS 1.0