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    Co-Localization to Chromosome Bands 99E1-3 of the Drosophila melanogaster Myosin Light Chain-2 Gene and a Haplo-Insufficient Locus That Affects Flight Behavior

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    Author/Creator
    Warmke, Jeffrey W.
    Kreuz, Andrew J.
    Falkenthal, Scott
    Date
    1989-05
    Type of Work
    12 pages
    Text
    journal articles
    Department
    Beverly K. Fine School of the Sciences
    Citation of Original Publication
    Warmke, J. W., Kreuz, A. J., & Falkenthal, S. (1989). Co-localization to chromosome bands 99E1-3 of the Drosophila melanogaster myosin light chain-2 gene and a haplo-insufficient locus that affects flight behavior. Genetics, 122(1), 139-151.
    Abstract
    Using overlapping synthetic deficiencies, we find that a haplo-insufficient locus affecting flight behavior and the myosin light chain-2 gene co-map to the Drosophila melanogaster polytene chromosome interval 99D9-E1 to 99E2-3. From screening over 9000 EMS-treated chromosomes, we obtained alleles of two complementation groups that map to this same interval. One of these complementation groups lfm(3)99Eb, exhibits dominant flightless behavior; thus, flightless behavior of the deficiency is in all likelihood due to hemizygosity of this single locus. Rescue of flightless behavior by a duplication indicates that the single allele, E38, of the Ifm(3)99Eb complementation group is a hypomorph. Based upon its map position and a reduction in concentration of myosin light chain-2 mRNA in heterozygotes, we propose that Ifm(3)Eb(E38) is a mutant allele of the myosin light chain-2 gene. Our genetic analysis also resulted in the identification of four dominant flightless alleles of an unlinked locus, l(3)nc99Eb, that exhibits dominant lethal synergism with Ifm(3)99Eb.


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    Stevenson University Library
    1525 Greenspring Valley Road
    Stevenson, MD 21153

    Website: http://stevensonlibrary.org

    Contact information:
    Elizabeth Fields
    efields2@stevenson.edu
    http://stevenson.libguides.com/sse


    If you wish to submit a copyright complaint or withdrawal request, please email mdsoar-help@umd.edu.