Stiatistical Issues in Meta-Analysis

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dc.contributor.advisorSinha, Bimal K
dc.contributor.advisorKnapp, Guido
dc.contributor.authorXu, Dihua
dc.contributor.departmentMathematics and Statistics
dc.contributor.programStatistics
dc.date.accessioned2015-10-14T03:12:42Z
dc.date.available2015-10-14T03:12:42Z
dc.date.issued2011-01-01
dc.description.abstractIn statistical meta-analysis paradigm dealing with the techniques of pooling of evidence across several studies, the notion of effect size is fundamental and it is necessary to perform appropriate tests for the equality of population effect sizes arising out of these studies before performing any meta-analysis. A well known test for homogeneity in this context is based on Cochran's chi-square statistic. However Cochran's test might be inaccurate in testing homogeneity for some effect sizes in the sense of not maintaining the stipulated Type I errors. In this dissertation, three such scenarios are identified: 1) testing homogeneity of standardized mean difference, 2) testing homogeneity of correlations and correlation matrices, and 3) testing homogeneity of proportions with low event rates, and in each case the severe inadequacy of Cochran's homogeneity test is demonstrated. Apppropriate bootstrap procedures for testing homogeneity hypotheses are suggested, and applications in each problem are indicated. Two additional problems are also dealt with in the dissertation: Mantel-Haenszel and Peto weights in random effects meta-analysis, and extraction methods in statistical meta-analysis.
dc.formatapplication/pdf
dc.genredissertations
dc.identifierdoi:10.13016/M26677
dc.identifier.other10448
dc.identifier.urihttp://hdl.handle.net/11603/1026
dc.languageen
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Theses and Dissertations Collection
dc.relation.ispartofUMBC Graduate School Collection
dc.relation.ispartofUMBC Student Collection
dc.relation.ispartofUMBC Mathematics and Statistics Department Collection
dc.rightsThis item may be protected under Title 17 of the U.S. Copyright Law. It is made available by UMBC for non-commercial research and education. For permission to publish or reproduce, please see http://aok.lib.umbc.edu/specoll/repro.php or contact Special Collections at speccoll(at)umbc.edu.
dc.sourceOriginal File Name: Xu_umbc_0434D_10448.pdf
dc.subjectAdverse Event
dc.subjectBootstrap
dc.subjectCochran's test
dc.subjectCorrelation Matrics
dc.subjectHomogeneity test
dc.subjectMeta-Analysis
dc.titleStiatistical Issues in Meta-Analysis
dc.typeText
dcterms.accessRightsAccess limited to the UMBC community. Item may possibly be obtained via Interlibrary Loan through a local library, pending author/copyright holder's permission.

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