Drosophila Corazonin Neurons as a Hub for Regulating Growth, Stress Responses, Ethanol-Related Behaviors, Copulation Persistence and Sexually Dimorphic Reward Pathways

Simple item page
dc.contributor.authorKhan, Ziam
dc.contributor.authorTondravi, Maya
dc.contributor.authorOliver, Ryan
dc.contributor.authorVonhoff, Fernando
dc.date.accessioned2021-07-23T22:40:16Z
dc.date.available2021-07-23T22:40:16Z
dc.date.issued2021-07-05
dc.description.abstractThe neuronal mechanisms by which complex behaviors are coordinated and timed often involve neuropeptidergic regulation of stress and reward pathways. Recent studies of the neuropeptide Corazonin (Crz), a homolog of the mammalian Gonadotrophin Releasing Hormone (GnRH), have suggested its crucial role in the regulation of growth, internal states and behavioral decision making. We focus this review on Crz neurons with the goal to (1) highlight the diverse roles of Crz neuron function, including mechanisms that may be independent of the Crz peptide, (2) emphasize current gaps in knowledge about Crz neuron functions, and (3) propose exciting ideas of novel research directions involving the use of Crz neurons. We describe the different developmental fates of distinct subsets of Crz neurons, including recent findings elucidating the molecular regulation of apoptosis. Crz regulates systemic growth, food intake, stress responses and homeostasis by interacting with the short Neuropeptide F (sNPF) and the steroid hormone ecdysone. Additionally, activation of Crz neurons is shown to be pleasurable by interacting with the Neuropeptide F (NPF) and regulates reward processes such as ejaculation and ethanol-related behaviors in a sexually dimorphic manner. Crz neurons are proposed to be a motivational switch regulating copulation duration using a CaMKII-dependent mechanism described as the first neuronal interval timer lasting longer than a few seconds. Lastly, we propose ideas to use Crz neuron-induced ejaculation to study the effects of fictive mating and sex addiction in flies, as well as to elucidate dimorphic molecular mechanisms underlying reward behaviors and feeding disorders.en_US
dc.description.sponsorshipThanks to the UMBC Natural Sciences Pre-Professoriate Fellowship for support to FJV. ZK and RO were supported by the Undergraduate Research Award program at UMBC, which is funded by the Division of Undergraduate Academic Affairs. MT was supported by the Meyerhoff Scholars Program, by a grant to UMBC from the Howard Hughes Medical Institute through the HHMI Adaptation Project, and by the U-RISE Program at UMBC. URISE at UMBC is supported by the National Institute of General Medical Sciences of the National Institutes of Health (NIGMS/NIH) under Award T34GM136497. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.en_US
dc.description.urihttps://www.mdpi.com/2221-3759/9/3/26en_US
dc.format.extent18 pagesen_US
dc.genrejournal articlesen_US
dc.identifierdoi:10.13016/m2czcd-ybnm
dc.identifier.citationKhan, Ziam et al.; Drosophila Corazonin Neurons as a Hub for Regulating Growth, Stress Responses, Ethanol-Related Behaviors, Copulation Persistence and Sexually Dimorphic Reward Pathways; Journal of Developmental Biology, 9(3), 26, 5 July, 2021; https://doi.org/10.3390/jdb9030026en_US
dc.identifier.urihttps://doi.org/10.3390/jdb9030026
dc.identifier.urihttp://hdl.handle.net/11603/22078
dc.language.isoen_USen_US
dc.publisherMDPIen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Biological Sciences Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.rightsAttribution 4.0 International (CC BY 4.0)*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.titleDrosophila Corazonin Neurons as a Hub for Regulating Growth, Stress Responses, Ethanol-Related Behaviors, Copulation Persistence and Sexually Dimorphic Reward Pathwaysen_US
dc.typeTexten_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
jdb-09-00026-v2.pdf
Size:
868.61 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
2.56 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

UMBC Biological Sciences Department
UMBC Faculty Collection