Activity Dependent Modulation of Granule Cell Survival in the Accessory Olfactory Bulb at Puberty

dc.contributor.authorOboti, Livio
dc.contributor.authorTrova, Sara
dc.contributor.authorSchellino, Roberta
dc.contributor.authorMarraudino, Marilena
dc.contributor.authorHarris, Natalie R.
dc.contributor.authorAbiona, Olubukola M.
dc.contributor.authorStampar, Mojca
dc.contributor.authorLin, Weihong
dc.contributor.authorPeretto, Paolo
dc.date.accessioned2021-03-29T16:26:00Z
dc.date.available2021-03-29T16:26:00Z
dc.date.issued2020-05-23
dc.description.abstractThe vomeronasal system (VNS) is specialized in the detection of salient chemical cues triggering social and neuroendocrine responses. Such responses are not always stereotyped, instead, they vary depending on age, sex, and reproductive state, yet the mechanisms underlying this variability are unclear. Here, by analyzing neuronal survival in the first processing nucleus of the VNS, namely the accessory olfactory bulb (AOB), through multiple bromodeoxyuridine birthdating protocols, we show that exposure of female mice to male soiled bedding material affects the integration of newborn granule interneurons mainly after puberty. This effect is induced by urine compounds produced by mature males, as bedding soiled by younger males was ineffective. The granule cell increase induced by mature male odor exposure is not prevented by pre-pubertal ovariectomy, indicating a lesser role of circulating estrogens in this plasticity. Interestingly, the intake of adult male urine-derived cues by the female vomeronasal organ increases during puberty, suggesting a direct correlation between sensory activity and AOB neuronal plasticity. Thus, as odor exposure increases the responses of newly born cells to the experienced stimuli, the addition of new GABAergic inhibitory cells to the AOB might contribute to the shaping of vomeronasal processing of male cues after puberty. Consistently, only after puberty, female mice are capable to discriminate individual male odors through the VNS.en_US
dc.description.sponsorshipWe would like to thank Aminah Sheikh, for proof-reading a revised copy of the manuscript. This work was supported by Progetti di Ricerca di Interesse Nazionale (PRIN)-Peretto 2010-2011, Ricerca Locale UNITO 2014-2015 (PP) and NIH/NIDCD DC012831 (WL).en_US
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fnana.2017.00044/fullen_US
dc.format.extent15 pagesen_US
dc.genrejournal articlesen_US
dc.identifierdoi:10.13016/m2pph1-4eum
dc.identifier.citationOboti L, Trova S, Schellino R, Marraudino M, Harris NR, Abiona OM, Stampar M, Lin W and Peretto P (2017) Activity Dependent Modulation of Granule Cell Survival in the Accessory Olfactory Bulb at Puberty. Front. Neuroanat. 11:44. doi: 10.3389/fnana.2017.00044en_US
dc.identifier.urihttps://doi.org/10.3389/fnana.2017.00044
dc.identifier.urihttp://hdl.handle.net/11603/21238
dc.language.isoen_USen_US
dc.publisherFrontiers Mediaen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Biological Sciences Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.relation.ispartofUMBC Student Collection
dc.relation.ispartofUMBC Meyerhoff Scholars Program
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.rightsAttribution 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.titleActivity Dependent Modulation of Granule Cell Survival in the Accessory Olfactory Bulb at Pubertyen_US
dc.typeTexten_US

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