Synthetic yeast brews neuroactive compounds
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Gu, Yang; Xu, Peng; Synthetic yeast brews neuroactive compounds; Nature Chemical Biology (2020); https://www.nature.com/articles/s41589-020-00691-5
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Metabolic engineering offers the flexibility to meet market demand for bioactive natural products but can be hampered when a necessary protein or intermediate is toxic. In yeast, modifying the subcellular localization of biosynthetic enzymes can alleviate toxicity and increase production titer.