Small Molecule NIR-II Dyes for Switchable Photoluminescence via Host –Guest Complexation and Supramolecular Assembly with Carbon Dots

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dc.contributor.authorSar, Dinabandhu
dc.contributor.authorOstadhossein, Fatemeh
dc.contributor.authorMoitra, Parikshit
dc.contributor.authorAlafeef, Maha
dc.contributor.authorPan, Dipanjan
dc.date.accessioned2022-06-28T20:36:14Z
dc.date.available2022-06-28T20:36:14Z
dc.date.issued2022-06-03
dc.description.abstractSmall molecular NIR-II dyes are highly desirable for various biomedical applications. However, NIR-II probes are still limited due to the complex synthetic processes and inadequate availability of fluorescent core. Herein, the design and synthesis of three small molecular NIR-II dyes are reported. These dyes can be excited at 850–915 nm and emitted at 1280–1290 nm with a large stokes shift (≈375 nm). Experimental and computational results indicate a 2:1 preferable host–guest assembly between the cucurbit[8]uril (CB) and dye molecules. Interestingly, the dyes when self-assembled in presence of CB leads to the formation of nanocubes (≈200 nm) and exhibits marked enhancement in fluorescence emission intensity (Switch-On). However, the addition of red carbon dots (rCDots, ≈10 nm) quenches the fluorescence of these host–guest complexes (Switch-Off) providing flexibility in the user-defined tuning of photoluminescence. The turn-ON complex found to have comparable quantum yield to the commercially available near-infrared fluorophore, IR-26. The aqueous dispersibility, cellular and blood compatibility, and NIR-II bioimaging capability of the inclusion complexes is also explored. Thus, a switchable fluorescence behavior, driven by host–guest complexation and supramolecular self-assembly, is demonstrated here for three new NIR-II dyes.en_US
dc.description.sponsorshipD.S., F.O., and P.M. contributed equally to this work. The authors gratefully acknowledge the receipt of funding from University of Illinois at Urbana-Champaign, NIBIB R03EB028026, University of Maryland Baltimore and University of Maryland Baltimore County. F.O. was funded by American Heart Association predoctoral fellowship (No. 18PRE34080003) and Beckman Institute postdoctoral fellowship. The authors acknowledge Subhendu Pandit and Esra Altun for their help some preliminary studies with DFT calculation and AFM studies, respectively. The authors thank Dr. Richard Haasch for help with XPS and Dr. Leilei Yin for help with AFM.en_US
dc.description.urihttps://onlinelibrary.wiley.com/doi/10.1002/advs.202202414en_US
dc.format.extent11 pagesen_US
dc.genrejournal articlesen_US
dc.identifierdoi:10.13016/m2jyqy-7ajm
dc.identifier.citationSar, D., Ostadhossein, F., Moitra, P., Alafeef, M., Pan, D., Small Molecule NIR-II Dyes for Switchable Photoluminescence via Host –Guest Complexation and Supramolecular Assembly with Carbon Dots. Adv. Sci. 2022, 2202414. https://doi.org/10.1002/advs.202202414en_US
dc.identifier.urihttps://doi.org/10.1002/advs.202202414
dc.identifier.urihttp://hdl.handle.net/11603/25073
dc.language.isoen_USen_US
dc.publisherWileyen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Chemical, Biochemical & Environmental Engineering Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.titleSmall Molecule NIR-II Dyes for Switchable Photoluminescence via Host –Guest Complexation and Supramolecular Assembly with Carbon Dotsen_US
dc.typeTexten_US
dcterms.creatorhttps://orcid.org/0000-0001-6603-2169en_US
dcterms.creatorhttps://orcid.org/0000-0003-0175-4704en_US

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