Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells

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dc.contributor.authorTeng, Yang D.
dc.contributor.authorLavik, Erin
dc.contributor.authorQu, Xianlu
dc.contributor.authorPark, Kook I.
dc.contributor.authorOurednik, Jitka
dc.contributor.authorZurakowski, David
dc.contributor.authorLanger, Robert
dc.contributor.authorSnyder, Evan Y.
dc.date.accessioned2021-03-19T16:59:31Z
dc.date.available2021-03-19T16:59:31Z
dc.date.issued2002-03-05
dc.descriptionProceedings of the National Academy of Sciences Mar 2002, 99 (5) 3024-3029en_US
dc.description.abstractTo better direct repair following spinal cord injury (SCI), we designed an implant modeled after the intact spinal cord consisting of a multicomponent polymer scaffold seeded with neural stem cells. Implantation of the scaffold–neural stem cells unit into an adult rat hemisection model of SCI promoted long-term improvement in function (persistent for 1 year in some animals) relative to a lesion-control group. At 70 days postinjury, animals implanted with scaffold-plus-cells exhibited coordinated, weight-bearing hindlimb stepping. Histology and immunocytochemical analysis suggested that this recovery might be attributable partly to a reduction in tissue loss from secondary injury processes as well as in diminished glial scarring. Tract tracing demonstrated corticospinal tract fibers passing through the injury epicenter to the caudal cord, a phenomenon not present in untreated groups. Together with evidence of enhanced local GAP-43 expression not seen in controls, these findings suggest a possible regeneration component. These results may suggest a new approach to SCI and, more broadly, may serve as a prototype for multidisciplinary strategies against complex neurological problemsen_US
dc.description.sponsorshipWe thank Umberto DeGirolami, Marion Slaney, Ali Shafarae, Karen Fu, Daniel Kohane, Larry Benowitz, and Carl Lagenaur for their assistance. This work was supported in part by Project ALS, National Institutes of Health 1-R21-NS41999-01, International Institute for Research in Paraplegia, and the A-T Children's Project, as well as a Harvard School of Dental Medicine/Massachusetts Institute of Technology National Institute of Dental and Craniofacial Research Training Grant in Biomaterials (to E.B.L.). R.L. holds equity in GMP Companies, which holds certain patents in this area.en_US
dc.description.urihttps://www.pnas.org/content/99/5/3024.longen_US
dc.format.extent7 pagesen_US
dc.genreconference papers and proceedingsen_US
dc.identifierdoi:10.13016/m21nvy-be8w
dc.identifier.citationYang D. Teng, Erin B. Lavik, Xianlu Qu, Kook I. Park, Jitka Ourednik, David Zurakowski, Robert Langer, Evan Y. Snyder, Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells, Proceedings of the National Academy of Sciences Mar 2002, 99 (5) 3024-3029; DOI: 10.1073/pnas.052678899en_US
dc.identifier.urihttps://doi.org/10.1073/pnas.052678899
dc.identifier.urihttp://hdl.handle.net/11603/21193
dc.language.isoen_USen_US
dc.publisherPNASen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Chemical, Biochemical & Environmental Engineering Department Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.subjectspinal cord injury
dc.subjectneural stem cells
dc.subjectmulticomponent polymer scaffold
dc.subjectfunctional long-term improvement
dc.titleFunctional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cellsen_US
dc.typeTexten_US

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