Neuropathology of Suicide A Review and an Approach

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dc.contributor.authorBachus, Susan E.
dc.contributor.authorHyde, Thomas M.
dc.contributor.authorAkil, Mayada
dc.contributor.authorWeickert, Cynthia Shannon
dc.contributor.authorVawter, Marquis P.
dc.contributor.authorKleinman, Joel E.
dc.date.accessioned2020-04-09T17:06:02Z
dc.date.available2020-04-09T17:06:02Z
dc.date.issued2006-12-17
dc.description.abstractNeuropathology is one approach to the effort to elucidate the pathophysiology of suicide. Initial neurochemical studies focusing on the roles of serotonin (5‐HT) and noradrenaline (NE) abnormalities in brains of suicide victims have been somewhat inconsistent. More recently developed methodologies, including quantitative receptor autoradiography, immunoblotting, immunohistochemistry, cell morphometry, in situ hybridization, Northern analysis, solution hybridization/RNase protection assay, reverse transcriptase polymerase chain reaction, and genotyping, which have already been applied successfully in studies of other disorders of brain structure or function, are now increasingly being adopted for postmortem studies of suicide. These new strategies are adding convergent evidence for brain 5‐HT and NE dysfunction in the etiology of suicide susceptibility, refining the neuroanatomical localization of this dysfunction, and in addition, implicating heretofore unsuspected candidate neurotransmitter systems in the neuropathological substrates of suicide susceptibility. It is argued here that the confluence of the availability of suitable postmortem samples and this augmentation of our armamentarium of techniques promises the attainment of important new insights into the biological underpinings of suicide from postmortem research. It is to be hoped that this new knowledge might inspire novel inspire novel pharmacotherapeutic strategies for the prevention of suicide.en_US
dc.description.urihttps://nyaspubs.onlinelibrary.wiley.com/doi/abs/10.1111/j.1749-6632.1997.tb52361.x?sid=nlm%3Apubmeden_US
dc.format.extent19 pagesen_US
dc.genrejournal articlesen_US
dc.identifierdoi:10.13016/m2anvb-wyyi
dc.identifier.citationBachus, Susan E.; Hyde, Thomas M.; Akil, Mayada; Weickert, Cynthia Shannon; Vawter, Marquis P.; Kleinman, Joel E.; Neuropathology of Suicide A Review and an Approach; Annals of the new york academic of sciences 836,1 (2006); https://nyaspubs.onlinelibrary.wiley.com/doi/abs/10.1111/j.1749-6632.1997.tb52361.x?sid=nlm%3Apubmeden_US
dc.identifier.urihttps://doi.org/10.1111/j.1749-6632.1997.tb52361.x
dc.identifier.urihttp://hdl.handle.net/11603/17908
dc.language.isoen_USen_US
dc.publisherWiley Online Libraryen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Psychology Department Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.rightsPublic Domain Mark 1.0*
dc.rightsThis work was written as part of one of the author's official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law.
dc.rights.urihttp://creativecommons.org/publicdomain/mark/1.0/*
dc.titleNeuropathology of Suicide A Review and an Approachen_US
dc.typeTexten_US

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