Efficacy of antiviral drug combinations against equine herpes virus type 1 in vitro

Simple item page
dc.contributor.advisorMargulies, Barry
dc.contributor.authorNandjou, Midrelle E.
dc.contributor.departmentTowson University. Department of Biological Sciences
dc.date.accessioned2015-12-17T19:36:13Z
dc.date.available2015-12-17T19:36:13Z
dc.date.issued2015-09-11
dc.date.submitted2015-08
dc.description(M.S.) -- Towson University, 2015.
dc.description.abstractEquine herpes virus type-1 (EHV-1) is responsible for a neurological infection in horses called equine herpes myeloencephalopathy (EHM). There is currently no specific treatment or vaccine licensed against the neuropathogenic EHV-1 strain (T953). In this study, the effect of combining the antiviral drugs cidofovir, foscarnet, and acyclovir was investigated. Specifically, we looked at the effect of using cidofovir + foscarnet and cidofovir + acyclovir against neuropathogenic EHV-1 (T953) propagated in equine dermal fibroblast (E. Derm) cells. This is the first study to look at the effect of combining different antiviral drugs against EHV-1 (T953). The combination of cidofovir (4 u/mL) + acyclovir (10 ?/mL) and cidofovir (7.5 ?/mL) + foscarnet (5 u/mL) were found to be non-toxic and to have an additive and no effect against EHV-1 (T953), respectively. These drug concentrations were also found to be non-toxic to E. Derm cells.
dc.formatapplication/pdf
dc.format.extentvii, 66 pages
dc.genretheses
dc.identifierdoi:10.13016/M2WD98
dc.identifier.otherTSU2015Nandjou
dc.identifier.urihttp://hdl.handle.net/11603/2072
dc.language.isoeng
dc.relation.ispartofTowson University Archives
dc.relation.ispartofTowson University Electronic Theses and Dissertations
dc.relation.ispartofTowson University Institutional Repository
dc.rightsCopyright protected, all rights reserved.
dc.titleEfficacy of antiviral drug combinations against equine herpes virus type 1 in vitro
dc.typeText
dcterms.accessRightsThere are no restrictions on access to this document. An internet release form signed by the author to display this document online is on file with Towson University Special Collections and Archives.

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
TSU2015Nandjou_redacted.pdf
Size:
1.85 MB
Format:
Adobe Portable Document Format
Download

Collections

Towson University Graduate Theses and Dissertations