The molecular basis of mechanisms underlying polarization vision

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dc.contributor.authorRoberts, Nicholas W.
dc.contributor.authorPorter, Megan L.
dc.contributor.authorCronin, Thomas W.
dc.date.accessioned2019-04-11T15:41:20Z
dc.date.available2019-04-11T15:41:20Z
dc.date.issued2011-03-12
dc.description.abstractThe underlying mechanisms of polarization sensitivity (PS) have long remained elusive. For rhabdomeric photoreceptors, questions remain over the high levels of PS measured experimentally. In ciliary photoreceptors, and specifically cones, little direct evidence supports any type of mechanism. In order to promote a greater interest in these fundamental aspects of polarization vision, we examined a varied collection of studies linking membrane biochemistry, protein–protein interactions, molecular ordering and membrane phase behaviour. While initially these studies may seem unrelated to polarization vision, a common narrative emerges. A surprising amount of evidence exists demonstrating the importance of protein–protein interactions in both rhabdomeric and ciliary photoreceptors, indicating the possible long-range ordering of the opsin protein for increased PS. Moreover, we extend this direction by considering how such protein paracrystalline organization arises in all cell types from controlled membrane phase behaviour and propose a universal pathway for PS to occur in both rhabdomeric and cone photoreceptors.en_US
dc.description.sponsorshipThe authors gratefully acknowledge the support from the National Science Foundation (IOS 0721608), the Air Force Office of Scientific Research (FA9550-09-1-0149) and from the Biotechnology and Biological Sciences Research Council (BB/G022917/1).en_US
dc.description.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3049014/en_US
dc.format.extent11 pagesen_US
dc.genrejournal articlesen_US
dc.identifierdoi:10.13016/m2sjrl-hurq
dc.identifier.citationNicholas W. Roberts1, Megan L. Porter and Thomas W. Cronin, The molecular basis of mechanisms underlying polarization vision, Phil. Trans. R. Soc. B (2011) 366, 627–637 ,DOI :10.1098/rstb.2010.0206en_US
dc.identifier.urihttps://doi.org/10.1098/rstb.2010.0206
dc.identifier.urihttp://hdl.handle.net/11603/13396
dc.language.isoen_USen_US
dc.publisherThe Royal Societyen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Biological Sciences Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.subjectpolarization sensitivityen_US
dc.subjectpolarization visionen_US
dc.subjectprotein interactionsen_US
dc.subjectmolecular tetheringen_US
dc.subjectmembrane compositionen_US
dc.subjectlipid raftsen_US
dc.titleThe molecular basis of mechanisms underlying polarization visionen_US
dc.typeTexten_US

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