Engineering Cell Surface Function with DNA Origami

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dc.contributor.authorAkbari, Ehsan
dc.contributor.authorMollica, Molly Y.
dc.contributor.authorLucas, Christopher R.
dc.contributor.authorBushman, Sarah M.
dc.contributor.authorPatton, Randy A.
dc.contributor.authorShahhosseini, Melika
dc.contributor.authorSong, Jonathan W.
dc.contributor.authorCastro, Carlos E.
dc.date.accessioned2023-08-14T17:27:34Z
dc.date.available2023-08-14T17:27:34Z
dc.date.issued2017-10-13
dc.description.abstractA specific and reversible method is reported to engineer cell-membrane function by embedding DNA-origami nanodevices onto the cell surface. Robust membrane functionalization across epithelial, mesenchymal, and nonadherent immune cells is achieved with DNA nanoplatforms that enable functions including the construction of higher-order DNA assemblies at the cell surface and programed cell–cell adhesion between homotypic and heterotypic cells via sequence-specific DNA hybridization. It is anticipated that integration of DNA-origami nanodevices can transform the cell membrane into an engineered material that can mimic, manipulate, and measure biophysical and biochemical function within the plasma membrane of living cells.en_US
dc.description.sponsorshipE.A. and M.Y.M. contributed equally to this work. This work was supported by grants from the National Science Foundation (Award no. 1351159 to CEC) and the American Heart Association (Award no. 15SDG25480000 to JWS and no. 17IRG33460357 to CEC). In addition, the work was partially supported by The Ohio State University Materials Research Seed Grant Program, funded by the Center for Emergent Materials, an NSF-MRSEC, grant DMR-1420451, the Center for Exploration of Novel Complex Materials, and the Institute for Materials Research. C.R.L. is a recipient of a National Institutes of Health T32 Award in Oncology Training Fellowship at The Ohio State University Comprehensive Cancer Center, T32 CA009338. The authors also thank Emily McKinnon for the preliminary design of the DNA origami structure.en_US
dc.description.urihttps://onlinelibrary.wiley.com/doi/10.1002/adma.201703632en_US
dc.description.urihttps://onlinelibrary.wiley.com/doi/abs/10.1002/adma.201770328
dc.format.extent18 pagesen_US
dc.genrejournal articlesen_US
dc.genrepostprintsen_US
dc.identifierdoi:10.13016/m2zlf3-osby
dc.identifier.citationAkbari, Ehsan, Molly Y. Mollica, Christopher R. Lucas, Sarah M. Bushman, Randy A. Patton, Melika Shahhosseini, Jonathan W. Song, and Carlos E. Castro. “Engineering Cell Surface Function with DNA Origami.” Advanced Materials 29, no. 46 (2017): 1703632. https://doi.org/10.1002/adma.201703632en_US
dc.identifier.urihttps://doi.org/10.1002/adma.201703632
dc.identifier.urihttp://hdl.handle.net/11603/29193
dc.language.isoen_USen_US
dc.publisherWileyen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Mechanical Engineering Department Collection
dc.rightsThis is the peer reviewed version of the following article: Akbari, Ehsan, Molly Y. Mollica, Christopher R. Lucas, Sarah M. Bushman, Randy A. Patton, Melika Shahhosseini, Jonathan W. Song, and Carlos E. Castro. “Engineering Cell Surface Function with DNA Origami.” Advanced Materials 29, no. 46 (2017): 1703632. https://doi.org/10.1002/adma.201703632, which has been published in final form at https://doi.org/10.1002/adma.201703632. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.en_US
dc.titleEngineering Cell Surface Function with DNA Origamien_US
dc.title.alternativeCell-Membrane Engineering: Engineering Cell Surface Function with DNA Origami
dc.title.alternativeCell-Membrane Engineering: Engineering Cell Surface Function with DNA Origami (Adv. Mater. 46/2017)
dc.typeTexten_US
dcterms.creatorhttps://orcid.org/0000-0002-5975-3539en_US

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