Effect of collaborative depression treatment on risk for diabetes: A 9-year follow-up of the IMPACT randomized controlled trial

dc.contributor.authorKhambaty, Tasneem
dc.contributor.authorCallahan, Christopher M.
dc.contributor.authorStewart, Jesse C.
dc.date.accessioned2018-09-12T20:33:19Z
dc.date.available2018-09-12T20:33:19Z
dc.date.issued2018-08-23
dc.description.abstractConsiderable epidemiologic evidence and plausible biobehavioral mechanisms suggest that depression is an independent risk factor for diabetes. Moreover, reducing the elevated diabetes risk of depressed individuals is imperative given that both conditions are leading causes of death and disability. However, because no prior study has examined clinical diabetes outcomes among depressed patients at risk for diabetes, the question of whether depression treatment prevents or delays diabetes onset remains unanswered. Accordingly, we examined the effect of a 12-month collaborative care program for late-life depression on 9-year diabetes incidence among depressed, older adults initially free of diabetes. Participants were 119 primary care patients [M (SD) age: 67.2 (6.9) years, 41% African American] with a depressive disorder but without diabetes enrolled at the Indiana sites of the Improving Mood-Promoting Access to Collaborative Treatment (IMPACT) trial. Incident diabetes cases were defined as diabetes diagnoses, positive laboratory values, or diabetes medication prescription, and were identified using electronic medical record and Medicare/Medicaid data. Surprisingly, the rate of incident diabetes in the collaborative care group was 37% (22/59) versus 28% (17/60) in the usual care group. Even though the collaborative care group exhibited greater reductions in depressive symptom severity (p = .024), unadjusted (HR = 1.29, 95% CI: 0.69–2.43, p = .428) and adjusted (HR = 1.18, 95% CI: 0.61–2.29, p = .616) Cox proportional hazards models indicated that the risk of incident diabetes did not differ between the treatment groups. Our novel preliminary findings raise the possibility that depression treatment alone may be insufficient to reduce the excess diabetes risk of depressed, older adults.en_US
dc.description.sponsorshipThis research was supported by the National Institute on Aging [grant numbers AG031222, AG024078] awarded to C.M.C., https://www.nia.nih.gov/. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en_US
dc.description.urihttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0200248en_US
dc.format.extent11 pagesen_US
dc.genrejournal articleen_US
dc.identifierdoi:10.13016/M21R6N42F
dc.identifier.citationKhambaty T, Callahan CM, Stewart JC (2018) Effect of collaborative depression treatment on risk for diabetes: A 9-year follow-up of the IMPACT randomized controlled trial. PLoS ONE 13(8): e0200248. https://doi.org/10.1371/journal.pone.0200248en_US
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0200248
dc.identifier.urihttp://hdl.handle.net/11603/11289
dc.language.isoen_USen_US
dc.publisherPLoS ONEen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Psychology Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.rightsThis item may be protected under Title 17 of the U.S. Copyright Law. It is made available by UMBC for non-commercial research and education. For permission to publish or reproduce, please contact the author.
dc.rightsAttribution 4.0 International (CC BY 4.0)*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectdiabetes mellitusen_US
dc.subjectdepression treatmenten_US
dc.subjectdepression as a risk factor for diabetes
dc.subjectreducing the elevated diabetes risk of depressed individuals
dc.subjectclinical diabetes outcomes among depressed patients at risk for diabetes
dc.subjectpreventing or delaying diabetes onset by treating depression
dc.subjectcollaborative care program
dc.subjectElderly
dc.titleEffect of collaborative depression treatment on risk for diabetes: A 9-year follow-up of the IMPACT randomized controlled trialen_US
dc.typeTexten_US

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