Synaptic silencing of fast muscle is compensated by rewired innervation of slow muscle

dc.contributor.authorZempo, Buntaro
dc.contributor.authorYamamoto, Yasuhiro
dc.contributor.authorWilliams, Tory
dc.contributor.authorOno, Fumihito
dc.date.accessioned2024-08-07T14:07:34Z
dc.date.available2024-08-07T14:07:34Z
dc.date.issued2020-04-08
dc.description.abstractFor decades, numerous studies have proposed that fast muscles contribute to quick movement, while slow muscles underlie locomotion requiring endurance. By generating mutant zebrafish whose fast muscles are synaptically silenced, we examined the contribution of fast muscles in both larval and adult zebrafish. In the larval stage, mutants lacked the characteristic startle response to tactile stimuli: bending of the trunk (C-bend) followed by robust forward propulsion. Unexpectedly, adult mutants with silenced fast muscles showed robust C-bends and forward propulsion upon stimulation. Retrograde labeling revealed that motor neurons genetically programmed to form synapses on fast muscles are instead rerouted and innervate slow muscles, which led to partial conversion of slow and intermediate muscles to fast muscles. Thus, extended silencing of fast muscle synapses changed motor neuron innervation and caused muscle cell type conversion, revealing an unexpected mechanism of locomotory adaptation.
dc.description.sponsorshipThis study was supported by Grant-in-Aid for Scientific Research (KAKENHI 18K06882 to F.O.) from the Japanese Ministry of Education, Culture, Sports, Science and Technology and internal grants from NIAAA/NIH and Osaka Medical College.
dc.description.urihttps://www.science.org/doi/10.1126/sciadv.aax8382
dc.format.extent12 pages
dc.genrejournal articles
dc.identifierdoi:10.13016/m2uscr-gq7y
dc.identifier.citationZempo, Buntaro, Yasuhiro Yamamoto, Tory Williams, and Fumihito Ono. “Synaptic Silencing of Fast Muscle Is Compensated by Rewired Innervation of Slow Muscle.” Science Advances 6, no. 15 (April 8, 2020): eaax8382. https://doi.org/10.1126/sciadv.aax8382.
dc.identifier.urihttps://doi.org/10.1126/sciadv.aax8382
dc.identifier.urihttp://hdl.handle.net/11603/35211
dc.language.isoen_US
dc.publisherAAAS
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Faculty Development Center (FDC)
dc.relation.ispartofUMBC Faculty Collection
dc.rightsATTRIBUTION-NONCOMMERCIAL 4.0 INTERNATIONAL
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.titleSynaptic silencing of fast muscle is compensated by rewired innervation of slow muscle
dc.typeText
dcterms.creatorhttps://orcid.org/0000-0002-3600-1174

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