Understanding the tumor immune microenvironment (TIME) for effective therapy

dc.contributor.authorBinnewies, Mikhail
dc.contributor.authorRoberts, Edward W.
dc.contributor.authorKersten, Kelly
dc.contributor.authorChan, Vincent
dc.contributor.authorFearon, Douglas F.
dc.contributor.authorMerad, Miriam
dc.contributor.authorCoussens, Lisa M.
dc.contributor.authorGabrilovich, Dmitry I.
dc.contributor.authorOstrand-Rosenberg, Suzanne
dc.contributor.authorHedrick, Catherine C.
dc.contributor.authorVonderheide, Robert H.
dc.contributor.authorPittet, Mikael J.
dc.contributor.authorJain, Rakesh K.
dc.contributor.authorZou, Weiping
dc.contributor.authorHowcroft, T. Kevin
dc.contributor.authorWoodhouse, Elisa C.
dc.contributor.authorWeinberg, Robert A.
dc.contributor.authorKrummel, Matthew F.
dc.date.accessioned2019-03-05T18:57:05Z
dc.date.available2019-03-05T18:57:05Z
dc.date.issued2018-04-23
dc.description.abstractThe clinical successes in immunotherapy have been both astounding and at the same time unsatisfactory. Countless patients with varied tumor types have seen pronounced clinical response with immunotherapeutic intervention; however, many more patients have experienced minimal or no clinical benefit when provided the same treatment. As technology has advanced, so has the understanding of the complexity and diversity of the immune context of the tumor microenvironment and its influence on response to therapy. It has been possible to identify different subclasses of immune environment that have an influence on tumor initiation and response and therapy; by parsing the unique classes and subclasses of tumor immune microenvironment (TIME) that exist within a patient’s tumor, the ability to predict and guide immunotherapeutic responsiveness will improve, and new therapeutic targets will be revealed.en_US
dc.description.urihttps://www.nature.com/articles/s41591-018-0014-xen_US
dc.format.extent23 pagesen_US
dc.genrejournal articles postprintsen_US
dc.identifierdoi:10.13016/m2b4dh-m4jn
dc.identifier.citationMikhail Binnewies, Edward W. Roberts,et.al, Understanding the tumor immune microenvironment (TIME) for effective therapy, Nat Med. 2018 May; 24(5): 541–550. , doi: 10.1038/s41591-018-0014-xen_US
dc.identifier.urihttps://dx.doi.org/10.1038%2Fs41591-018-0014-x
dc.identifier.urihttp://hdl.handle.net/11603/12933
dc.language.isoen_USen_US
dc.publisherSpringer Nature Publishing AGen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Biological Sciences Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.subjectimmunotherapyen_US
dc.subjecttumor immune microenvironment (TIME)en_US
dc.subjectimmune-checkpoint blockade (ICB)en_US
dc.titleUnderstanding the tumor immune microenvironment (TIME) for effective therapyen_US
dc.typeTexten_US

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