In silico analysis reveals substantial variability in the gene contents of the gamma proteobacteria LexA-regulon

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dc.contributor.authorErill, Ivan
dc.contributor.authorEscribano, Marcos
dc.contributor.authorCampoy, Susana
dc.contributor.authorBarbé, Jordi
dc.date.accessioned2021-03-10T16:54:11Z
dc.date.available2021-03-10T16:54:11Z
dc.date.issued2003-11-22
dc.description.abstractMotivation: Motif-prediction algorithm capabilities for the analysis of bacterial regulatory networks and the prediction of new regulatory sites can be greatly enhanced by the use of comparative genomics approaches. In this study, we make use of a consensus-building algorithm and comparative genomics to conduct an in-depth analysis of the LexA-regulon of gamma proteobacteria, and we use the inferred results to study the evolution of this regulatory network and to examine the usefulness of the control sequences and gene contents of regulons in phylogenetic analysis. Results: We show, for the first time, the substantial heterogeneity that the LexA-regulon of gamma proteobacteria displays in terms of gene content and we analyze possible branching points in its evolution. We also demonstrate the feasibility of using regulon-related information to derive sound phylogenetic inferences.en_US
dc.description.sponsorshipThis work was partly funded by the Consejo de Investigaciones Científicas (CSIC) and by grants BMC2001-2065 from the Ministerio de Ciencia y Tecnología (MCyT) de España and 2001SGR-206 from the Departament d’Universitats, Recerca i Societat de la Informació (DURSI) de la Generalitat de Catalunya.en_US
dc.description.urihttps://academic.oup.com/bioinformatics/article/19/17/2225/205876en_US
dc.format.extent12 pagesen_US
dc.genrejournal articlesen_US
dc.identifierdoi:10.13016/m2msk0-z2cs
dc.identifier.citationIvan Erill, Marcos Escribano, Susana Campoy, Jordi Barbé, In silico analysis reveals substantial variability in the gene contents of the gamma proteobacteria LexA-regulon, Bioinformatics, Volume 19, Issue 17, 22 November 2003, Pages 2225–2236, https://doi.org/10.1093/bioinformatics/btg303en_US
dc.identifier.urihttps://doi.org/10.1093/bioinformatics/btg303
dc.identifier.urihttp://hdl.handle.net/11603/21134
dc.language.isoen_USen_US
dc.publisherOxford Academicen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Biological Sciences Department Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.subjectgamma proteobacteriaen_US
dc.subjectLexA-regulonen_US
dc.subjectcomparative genomicsen_US
dc.subjectconsensus-buliding approach
dc.subjectLexA-regulon of gamma proteobacteria
dc.titleIn silico analysis reveals substantial variability in the gene contents of the gamma proteobacteria LexA-regulonen_US
dc.typeTexten_US

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