Effect of an Oscillating Magnetic Field on the Release Properties of Magnetic Collagen Gels

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dc.contributor.authorDe Paoli, Vania M.
dc.contributor.authorLacerda, Silvia H. De Paoli
dc.contributor.authorSpinu, Leonard
dc.contributor.authorIngber, Bruce
dc.contributor.authorRosenzweig, Zeev
dc.contributor.authorRosenzweig, Nitsa
dc.date.accessioned2021-04-19T16:14:11Z
dc.date.available2021-04-19T16:14:11Z
dc.date.issued2006-05-13
dc.description.abstractThe paper describes the effect of an oscillating magnetic field (OMF) on the morphology and release properties of collagen gels containing magnetic nanoparticles and microparticles and fluorescent drug analogues. Collagen gels were prepared through fibrillogenesis of collagen in the presence of iron oxide magnetic particles averaging 10 nm or 3 μm in diameter and rhodamine-labeled dextran (Dex-R) of molecular weights between 3000−70 000 g/mol. Dextran molecules effectively simulate protein-based drugs, since they have similar molecular weights and dimensions. The paper discusses the effect of an OMF on the release properties of the gels and proposes an empirical model to predict the release rate. It also demonstrates the self-repair capability of collagen gels following the structural damage caused by an OMF.en_US
dc.description.sponsorshipThe authors thank Charles O’Connor and co-workers for providing magnetic nanoparticles needed to carry out the study. The authors also thank Laurie Locascio and Michael Gaitan of the National Institute of Standards and Technology (NIST) in Gaithersburg, MD, and the NIST administration for hosting our research group at NIST in the aftermath of Hurricane Katrina. Funding for the study was provided by DoD/DARPA grant HR0011-04-C-0068, NSF grant CHE-0314027, and a research grant from Cancer Association of Greater New Orleans (CAGNO) and the Louisiana Breast Cancer Task Force (LBCTF).en_US
dc.description.urihttps://pubs.acs.org/doi/abs/10.1021/la060280hen_US
dc.format.extent2 filesen_US
dc.genrejournal articlesen_US
dc.identifierdoi:10.13016/m2zpdq-tvak
dc.identifier.citationDe Paoli, Vania M.; Lacerda, Silvia H. De Paoli; Spinu, Leonard; Ingber, Bruce; Rosenzweig, Zeev; Rosenzweig, Nitsa; Effect of an Oscillating Magnetic Field on the Release Properties of Magnetic Collagen Gels; Langmuir 22, 13, 5894–5899 (2006); https://pubs.acs.org/doi/abs/10.1021/la060280hen_US
dc.identifier.urihttps://doi.org/10.1021/la060280h
dc.identifier.urihttp://hdl.handle.net/11603/21348
dc.language.isoen_USen_US
dc.publisherACS Publicationsen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Chemistry & Biochemistry Department Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.rightsPublic Domain Mark 1.0
dc.rightsThis work was written as part of one of the author's official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law.
dc.rights.urihttp://creativecommons.org/publicdomain/mark/1.0/
dc.titleEffect of an Oscillating Magnetic Field on the Release Properties of Magnetic Collagen Gelsen_US
dc.typeTexten_US

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