Three-dimensional optical trapping and orientation of microparticles for coherent X-ray diffraction imaging

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dc.contributor.authorGao, Yuan
dc.contributor.authorHarder, Ross
dc.contributor.authorSouthworth, Stephen H.
dc.contributor.authorGuest, Jeffrey R.
dc.contributor.authorHuang, Xiaojing
dc.contributor.authorYan, Zijie
dc.contributor.authorOcola, Leonidas E.
dc.contributor.authorYifat, Yuval
dc.contributor.authorSule, Nishant
dc.contributor.authorHo, Phay J.
dc.contributor.authorPelton, Matthew
dc.contributor.authorScherer, Norbert F.
dc.contributor.authorYoung, Linda
dc.date.accessioned2022-06-07T16:20:58Z
dc.date.available2022-06-07T16:20:58Z
dc.date.issued2019-02-14
dc.description.abstractOptical trapping has been implemented in many areas of physics and biology as a noncontact sample manipulation technique to study the structure and dynamics of nano- and mesoscale objects. It provides a unique approach for manipulating microscopic objects without inducing undesired changes in structure. Combining optical trapping with hard X-ray microscopy techniques, such as coherent diffraction imaging and crystallography, provides a nonperturbing environment where electronic and structural dynamics of an individual particle in solution can be followed in situ. It was previously shown that optical trapping allows the manipulation of micrometer-sized objects for X-ray fluorescence imaging. However, questions remain over the ability of optical trapping to position objects for X-ray diffraction measurements, which have stringent requirements for angular stability. Our work demonstrates that dynamic holographic optical tweezers are capable of manipulating single micrometer-scale anisotropic particles in a microfluidic environment with the precision and stability required for X-ray Bragg diffraction experiments—thus functioning as an “optical goniometer.” The methodology can be extended to a variety of X-ray experiments and the Bragg coherent diffractive imaging of individual particles in solution, as demonstrated here, will be markedly enhanced with the advent of brighter, coherent X-ray sources.en_US
dc.description.urihttps://www.pnas.org/doi/10.1073/pnas.1720785116en_US
dc.identifierdoi:10.13016/m2tlji-bejw
dc.identifier.citationGao, Yuan et al. Three-dimensional optical trapping and orientation of microparticles for coherent X-ray diffraction imaging. PNAS 116 (Feb. 14, 2019), no. 10: 4018-4024. https://doi.org/10.1073/pnas.1720785116en_US
dc.identifier.urihttps://doi.org/10.1073/pnas.1720785116
dc.identifier.urihttp://hdl.handle.net/11603/24832
dc.language.isoen_USen_US
dc.publisherPNASen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Physics Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.en_US
dc.subjectoptical tweezersen_US
dc.subjectcoherent X-ray diffraction imagingen_US
dc.subjectmicrofluidicen_US
dc.subjectoptical trappingen_US
dc.subjectnanoscienceen_US
dc.titleThree-dimensional optical trapping and orientation of microparticles for coherent X-ray diffraction imagingen_US
dc.typeTexten_US
dcterms.creatorhttps://orcid.org/0000-0002-6370-8765en_US

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