Three-dimensional optical trapping and orientation of microparticles for coherent X-ray diffraction imaging
dc.contributor.author | Gao, Yuan | |
dc.contributor.author | Harder, Ross | |
dc.contributor.author | Southworth, Stephen H. | |
dc.contributor.author | Guest, Jeffrey R. | |
dc.contributor.author | Huang, Xiaojing | |
dc.contributor.author | Yan, Zijie | |
dc.contributor.author | Ocola, Leonidas E. | |
dc.contributor.author | Yifat, Yuval | |
dc.contributor.author | Sule, Nishant | |
dc.contributor.author | Ho, Phay J. | |
dc.contributor.author | Pelton, Matthew | |
dc.contributor.author | Scherer, Norbert F. | |
dc.contributor.author | Young, Linda | |
dc.date.accessioned | 2022-06-07T16:20:58Z | |
dc.date.available | 2022-06-07T16:20:58Z | |
dc.date.issued | 2019-02-14 | |
dc.description.abstract | Optical trapping has been implemented in many areas of physics and biology as a noncontact sample manipulation technique to study the structure and dynamics of nano- and mesoscale objects. It provides a unique approach for manipulating microscopic objects without inducing undesired changes in structure. Combining optical trapping with hard X-ray microscopy techniques, such as coherent diffraction imaging and crystallography, provides a nonperturbing environment where electronic and structural dynamics of an individual particle in solution can be followed in situ. It was previously shown that optical trapping allows the manipulation of micrometer-sized objects for X-ray fluorescence imaging. However, questions remain over the ability of optical trapping to position objects for X-ray diffraction measurements, which have stringent requirements for angular stability. Our work demonstrates that dynamic holographic optical tweezers are capable of manipulating single micrometer-scale anisotropic particles in a microfluidic environment with the precision and stability required for X-ray Bragg diffraction experiments—thus functioning as an “optical goniometer.” The methodology can be extended to a variety of X-ray experiments and the Bragg coherent diffractive imaging of individual particles in solution, as demonstrated here, will be markedly enhanced with the advent of brighter, coherent X-ray sources. | en_US |
dc.description.uri | https://www.pnas.org/doi/10.1073/pnas.1720785116 | en_US |
dc.identifier | doi:10.13016/m2tlji-bejw | |
dc.identifier.citation | Gao, Yuan et al. Three-dimensional optical trapping and orientation of microparticles for coherent X-ray diffraction imaging. PNAS 116 (Feb. 14, 2019), no. 10: 4018-4024. https://doi.org/10.1073/pnas.1720785116 | en_US |
dc.identifier.uri | https://doi.org/10.1073/pnas.1720785116 | |
dc.identifier.uri | http://hdl.handle.net/11603/24832 | |
dc.language.iso | en_US | en_US |
dc.publisher | PNAS | en_US |
dc.relation.isAvailableAt | The University of Maryland, Baltimore County (UMBC) | |
dc.relation.ispartof | UMBC Physics Department Collection | |
dc.relation.ispartof | UMBC Faculty Collection | |
dc.rights | This item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author. | en_US |
dc.subject | optical tweezers | en_US |
dc.subject | coherent X-ray diffraction imaging | en_US |
dc.subject | microfluidic | en_US |
dc.subject | optical trapping | en_US |
dc.subject | nanoscience | en_US |
dc.title | Three-dimensional optical trapping and orientation of microparticles for coherent X-ray diffraction imaging | en_US |
dc.type | Text | en_US |
dcterms.creator | https://orcid.org/0000-0002-6370-8765 | en_US |
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