Plasma neurofilament light and brain volumetric outcomes among middle-aged urban adults

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dc.contributor.authorBeydoun, May A.
dc.contributor.authorHooten, Nicole Noren
dc.contributor.authorBeydoun, Hind A.
dc.contributor.authorWeiss, Jordan
dc.contributor.authorMaldonado, Ana I.
dc.contributor.authorKatzel, Leslie I.
dc.contributor.authorDavatzikos, Christos
dc.contributor.authorGullapalli, Rao P.
dc.contributor.authorSeliger, Stephen L.
dc.contributor.authorErus, Guray
dc.contributor.authorEvans, Michele K.
dc.contributor.authorZonderman, Alan B.
dc.contributor.authorWaldstein, Shari R.
dc.date.accessioned2023-05-25T19:52:39Z
dc.date.available2023-05-25T19:52:39Z
dc.date.issued2023-05-02
dc.description.abstractElevated plasma neurofilament light chain (NfL) is associated with dementia, though underlying mechanisms remain unknown. We examined cross-sectional relationships of time-dependent plasma NfL with selected brain structural magnetic resonance imaging (sMRI) prognostic markers of dementia. The sample was drawn from the Healthy Aging in Neighborhoods of Diversity Across the Life Span (HANDLS) study, selecting participants with complete v₁ (2004-2009) and v₂ (2009-2013) plasma NfL exposure and ancillary sMRI data at vₛcₐₙ (2011-2015, n=179, mean v1 to vₛcₐₙ time: 5.4y). Multivariable-adjusted linear regression models were conducted, overall, by sex, and by race, correcting for multiple testing with q-values. NfL(ᵥ₁) was associated with larger WMLV (both Loge transformed), after 5-6 years’ follow-up, overall (β=+2.131±0.660, b=+0.29, p=0.001, q=0.0029) and among females. NfL(ᵥ₂) was linked to a 125 mm³ lower left hippocampal volume (p=0.004, q=0.015) in reduced models, mainly among males, as was observed for annualized longitudinal change in NfL (𝛿NfLbₐyₑₛ). Among African American adults, NfL(ᵥ₁) was inversely related to total, gray and white matter volumes. Plasma NfL may reflect future brain pathologies in middle-aged adults.en_US
dc.description.sponsorshipThis work was supported in part by the Intramural Research Program of the NIH, National Institute on Aging. This work was also supported by the National Institutes of Health, R01- AG034161 and P30 AG028747-14S1 to S.R.W, ZIA–AG000513 to M.K.E. and A.B.Z., and The University of Maryland Claude D. Pepper Older Americans Independence Center (NIH grant P30 AG028747)en_US
dc.description.urihttps://www.sciencedirect.com/science/article/pii/S019745802300091Xen_US
dc.format.extent47 pagesen_US
dc.genrejournal articlesen_US
dc.genrepostprintsen_US
dc.identifierdoi:10.13016/m28dyx-bvkg
dc.identifier.citationBeydoun, May A., et al. "Plasma neurofilament light and brain volumetric outcomes among middle-aged urban adults" Neurobiology of Aging (02 May,2023). https://doi.org/10.1016/j.neurobiolaging.2023.04.013.en_US
dc.identifier.urihttps://doi.org/10.1016/j.neurobiolaging.2023.04.013
dc.identifier.urihttp://hdl.handle.net/11603/28088
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Psychology Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.relation.ispartofUMBC Student Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
dc.rightsAccess to this item will begin on 05/02/2024
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titlePlasma neurofilament light and brain volumetric outcomes among middle-aged urban adultsen_US
dc.typeTexten_US
dcterms.creatorhttps://orcid.org/0000-0002-7247-3363en_US

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