Differential accumulation of extra-ribosomal L5(uL18) in response to various ribosomal stresses in a p53-free system

Abstract

Ribosome biogenesis is a highly regulated high-energy requiring process; it is coordinated with cell cycle and proliferation. Defects in ribosome assembly are connected with abnormal growth-related diseases. Ribosomal protein L5 is reported to involve regulating level of tumor-suppressor protein p53 in metazoans. Although the presence of extra-ribosomal L5 is reported in multiple organisms, systematic characterization of its fate in ribosome biogenesis stresses remains to be explored. Here we checked the fate of L5 in various nucleolar/ribosome stresses and commented on possible source of the accumulation. The variation in L5 accumulation may provide further understanding of different cell surveillance mechanisms.