Protein–Hydrogel Interactions in Tissue Engineering: Mechanisms and Applications

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dc.contributor.authorZustiak, Silviya P.
dc.contributor.authorWei, Yunqian
dc.contributor.authorLeach, Jennie B.
dc.date.accessioned2018-12-17T15:25:59Z
dc.date.available2018-12-17T15:25:59Z
dc.date.issued2012-11-13
dc.description.abstractRecent advances in our understanding of the sophistication of the cellular microenvironment and the dynamics of tissue remodeling during development, disease, and regeneration have increased our appreciation of the current challenges facing tissue engineering. As this appreciation advances, we are better equipped to approach problems in the biology and therapeutics of even more complex fields, such as stem cells and cancer. To aid in these studies, as well as the established areas of tissue engineering, including cardiovascular, musculoskeletal, and neural applications, biomaterials scientists have developed an extensive array of materials with specifically designed chemical, mechanical, and biological properties. Herein, we highlight an important topic within this area of biomaterials research, protein–hydrogel interactions. Due to inherent advantages of hydrated scaffolds for soft tissue engineering as well as specialized bioactivity of proteins and peptides, this field is well-posed to tackle major needs within emerging areas of tissue engineering. We provide an overview of the major modes of interactions between hydrogels and proteins (e.g., weak forces, covalent binding, affinity binding), examples of applications within growth factor delivery and three-dimensional scaffolds, and finally future directions within the area of hydrogel–protein interactions that will advance our ability to control the cell–biomaterial interface.en_US
dc.description.sponsorshipWe acknowledge NIH-NINDS R01NS065205 and funds from the Intramural Research Program of The Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH for supporting this work.en_US
dc.description.urihttps://www.ncbi.nlm.nih.gov/pubmed/23150926en_US
dc.format.extent12 pagesen_US
dc.genrejournal articlesen_US
dc.identifierdoi:10.13016/M2TM7251H
dc.identifier.citationSilviya P. Zustiak, Yunqian Wei, and Jennie B. Leach, Protein–Hydrogel Interactions in Tissue Engineering: Mechanisms and Applications, Tissue Engineering Part B: Reviews, Vol. 19, No. 2, 2012, https://doi.org/10.1089/ten.teb.2012.0458en_US
dc.identifier.urihttps://doi.org/10.1089/ten.teb.2012.0458
dc.identifier.urihttp://hdl.handle.net/11603/12275
dc.language.isoen_USen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Chemical, Biochemical & Environmental Engineering Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.subjectprotein-hydrogelen_US
dc.subjecttissue engineeringen_US
dc.subjectcardiovascularen_US
dc.subjectmusculoskeletalen_US
dc.subjectneural applicationsen_US
dc.titleProtein–Hydrogel Interactions in Tissue Engineering: Mechanisms and Applicationsen_US
dc.typeTexten_US

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