Intratumoral generation of photothermal gold nanoparticles through a vectorized biomineralization of ionic gold

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dc.contributor.authorSchwartz-Duval, Aaron S.
dc.contributor.authorKonopka, Christian J.
dc.contributor.authorMoitra, Parikshit
dc.contributor.authorDaza, Enrique A.
dc.contributor.authorSrivastava, Indrajit
dc.contributor.authorJohnson, Elyse V.
dc.contributor.authorKampert, Taylor L.
dc.contributor.authorFayn, Stanley
dc.contributor.authorHaran, Anand
dc.contributor.authorDobrucki, Lawrence W.
dc.contributor.authorPan, Dipanjan
dc.date.accessioned2020-10-07T17:57:13Z
dc.date.available2020-10-07T17:57:13Z
dc.date.issued2020-09-10
dc.description.abstractVarious cancer cells have been demonstrated to have the capacity to form plasmonic gold nanoparticles when chloroauric acid is introduced to their cellular microenvironment. But their biomedical applications are limited, particularly considering the millimolar concentrations and longer incubation period of ionic gold. Here, we describe a simplistic method of intracellular biomineralization to produce plasmonic gold nanoparticles at micromolar concentrations within 30 min of application utilizing polyethylene glycol as delivery vector for ionic gold. We have characterized this process for intracellular gold nanoparticle formation, which progressively accumulates proteins as the ionic gold clusters migrate to the nucleus. This nano-vectorized application of ionic gold emphasizes its potential biomedical opportunities while reducing the quantity of ionic gold and required incubation time. To demonstrate its biomedical potential, we further induce in-situ biosynthesis of gold nanoparticles within MCF7 tumor mouse xenografts which is followed by its photothermal remediation.en_US
dc.description.sponsorshipWe thank Frederick Seitz Materials Research Laboratory Central Research Facilities, and the Beckman research institute. Authors gratefully acknowledge funding from the University of Illinois at Urbana-Champaign, National Institute of Health (R03EB028026), and National Science Foundation. A.S.S.-D. gratefully acknowledges fellowship funding from the American Heart Association (16PRE30150004) and the NIH (5T32CA196561-05). Authors also acknowledge the receipt of funding from University of Maryland Baltimore and University of Maryland Baltimore County.en_US
dc.description.urihttps://www.nature.com/articles/s41467-020-17595-6#Abs1en_US
dc.format.extent18 pagesen_US
dc.genrejournal articlesen_US
dc.identifierdoi:10.13016/m2tkhc-j5lt
dc.identifier.citationSchwartz-Duval, A.S., Konopka, C.J., Moitra, P. et al. Intratumoral generation of photothermal gold nanoparticles through a vectorized biomineralization of ionic gold. Nat Commun 11, 4530 (2020). https://doi.org/10.1038/s41467-020-17595-6en_US
dc.identifier.urihttps://doi.org/10.1038/s41467-020-17595-6
dc.identifier.urihttp://hdl.handle.net/11603/19759
dc.language.isoen_USen_US
dc.publisherSpringer Natureen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Chemical, Biochemical & Environmental Engineering Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.rightsAttribution 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.titleIntratumoral generation of photothermal gold nanoparticles through a vectorized biomineralization of ionic golden_US
dc.typeTexten_US

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