Expanding the Diversity of Mycobacteriophages: Insights into Genome Architecture and Evolution

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dc.contributorAziz, Ramy
dc.contributor.authorPope, Welkin H.
dc.contributor.authorJacobs-Sera, Deborah
dc.contributor.authorRussell, Daniel A.
dc.contributor.authorPeebles, Craig L.
dc.contributor.authorAl-Atrache, Zein
dc.contributor.authorAlcoser, Turi A.
dc.contributor.authorAlexander, Lisa M.
dc.contributor.authorAlfano, Matthew B.
dc.contributor.authorAlford, Samantha T.
dc.contributor.authorAmy, Nichols E.
dc.contributor.authorAnderson, Marie D.
dc.contributor.authorAnderson, Alexander G.
dc.contributor.authorAng, Andrew A. S.
dc.contributor.authorAres, Manuel Jr.
dc.contributor.authorBarber, Amanda J.
dc.contributor.authorBarker, Lucia P.
dc.contributor.authorBarrett, Jonathan M.
dc.contributor.authorBarshop, William D.
dc.contributor.authorBauerle, Cynthia M.
dc.contributor.authorBayles, Ian M.
dc.contributor.authorBelfield, Katherine L.
dc.contributor.authorBest, Aaron A.
dc.contributor.authorBorjon, Agustin Jr.
dc.contributor.authorBowman, Charles A.
dc.contributor.authorBoyer, Christine A.
dc.contributor.authorBradley, Kevin W.
dc.contributor.authorBradley, Victoria A.
dc.contributor.authorBroadway, Lauren N.
dc.contributor.authorBudwal, Keshav
dc.contributor.authorBusby, Kayla N.
dc.contributor.authorCampbell, Ian W.
dc.contributor.authorCampbell, Anne M.
dc.contributor.authorCarey, Alyssa
dc.contributor.authorCaruso, Steven M.
dc.contributor.authorChew, Rebekah D.
dc.contributor.authorCockburn, Chelsea L.
dc.contributor.authorCohen, Lianne B.
dc.contributor.authorCorajod, Jeffrey M.
dc.contributor.authorCresawn, Steven G.
dc.contributor.authorDavis, Kimberly R.
dc.contributor.authorDeng, Lisa
dc.contributor.authorDenver, Dee R.
dc.contributor.authorDixon, Breyon R.
dc.contributor.authorEkram, Sahrish
dc.contributor.authorElgin, Sarah C. R.
dc.contributor.authorEngelsen, Angela E.
dc.contributor.authorEnglish, Belle E. V.
dc.contributor.authorErb, Marcella L.
dc.contributor.authorEstrada, Crystal
dc.contributor.authorFilliger, Laura Z.
dc.contributor.authorFindley, Ann M.
dc.contributor.authorForbes, Lauren
dc.contributor.authorForsyth, Mark H.
dc.contributor.authorFox, Tyler M.
dc.contributor.authorFritz, Melissa J.
dc.contributor.authorGarcia, Roberto
dc.contributor.authorGeorge, Zindzi D.
dc.contributor.authorGeorges, Anne E.
dc.contributor.authorGissendanner, Christopher R.
dc.contributor.authorGoff, Shannon
dc.contributor.authorGoldstein, Rebecca
dc.contributor.authorGordon, Kobie C.
dc.contributor.authorGreen, Russell D.
dc.contributor.authorGuerra, Stephanie L.
dc.contributor.authorGuiney-Olsen, Krysta R.
dc.contributor.authorGuiza, Bridget G.
dc.contributor.authorHaghighat, Leila
dc.contributor.authorHagopian, Garrett V.
dc.contributor.authorHarmon, Catherine J.
dc.contributor.authorHarmson, Jeremy S.
dc.contributor.authorHartzog, Grant A.
dc.contributor.authorHarvey, Samuel E.
dc.contributor.authorHe, Siping
dc.contributor.authorHe, Kevin J.
dc.contributor.authorHealy, Kaitlin E.
dc.contributor.authorHiginbotham, Ellen R.
dc.contributor.authorHildebrandt, Erin N.
dc.contributor.authorHo, Jason H.
dc.contributor.authorHogan, Gina M.
dc.contributor.authorHohenstein, Victoria G.
dc.contributor.authorHolz, Nathan A.
dc.contributor.authorHuang, Vincent J.
dc.contributor.authorHufford, Ericka L.
dc.contributor.authorHynes, Peter M.
dc.contributor.authorJackson, Arrykka S.
dc.contributor.authorJansen, Erica C.
dc.contributor.authorJarvik, Jonathan
dc.contributor.authorJasinto, Paul G.
dc.contributor.authorJordan, Tuajuanda C.
dc.contributor.authorKasza, Tomas
dc.contributor.authorKatelyn, Murray A.
dc.contributor.authorKelsey, Jessica S.
dc.contributor.authorKerrigan, Larisa A.
dc.contributor.authorKhaw, Daryl
dc.contributor.authorKim, Junghee
dc.contributor.authorKnutter, Justin Z.
dc.contributor.authorKo, Ching-Chung
dc.contributor.authorLarkin, Gail V.
dc.contributor.authorLaroche, Jennifer R.
dc.contributor.authorLatif, Asma
dc.contributor.authorLeuba, Kohana D.
dc.contributor.authorLeuba, Sequoia I.
dc.contributor.authorLewis, Lynn O.
dc.contributor.authorLoesser-Casey, Kathryn E.
dc.contributor.authorLong, Courtney A.
dc.contributor.authorLopez, A. Javier
dc.contributor.authorLowery, Nicholas
dc.contributor.authorLu, Tina Q.
dc.contributor.authorMac, Victor
dc.contributor.authorMasters, Isaac R.
dc.contributor.authorMcCloud, Jazmyn J.
dc.contributor.authorMcDonough, Molly J.
dc.contributor.authorMedenbach, Andrew J.
dc.contributor.authorMenon, Anjali
dc.contributor.authorMiller, Rachel
dc.contributor.authorMorgan, Brandon K.
dc.contributor.authorNg, Patrick C.
dc.contributor.authorNguyen, Elvis
dc.contributor.authorNguyen, Katrina T.
dc.contributor.authorNguyen, Emilie T.
dc.contributor.authorNicholson, Kaylee M.
dc.contributor.authorParnell, Lindsay A.
dc.contributor.authorPeirce, Caitlin E.
dc.contributor.authorPerz, Allison M.
dc.contributor.authorPeterson, Luke J.
dc.contributor.authorPferdehirt, Rachel E.
dc.contributor.authorPhilip, Seegren V.
dc.contributor.authorPogliano, Kit
dc.contributor.authorPogliano, Joe
dc.contributor.authorPolley, Tamsen
dc.contributor.authorPuopolo, Erica J.
dc.contributor.authorRabinowitz, Hannah S.
dc.contributor.authorResiss, Michael J.
dc.contributor.authorRhyan, Corwin N.
dc.contributor.authorRobinson, Yetta M.
dc.contributor.authorRodriguez, Lauren L.
dc.contributor.authorRose, Andrew C.
dc.contributor.authorRubin, Jeffrey D.
dc.contributor.authorRuby, Jessica A.
dc.contributor.authorSaha, Margaret S.
dc.contributor.authorSandoz, James W.
dc.contributor.authorSavitskaya, Judith
dc.contributor.authorSchipper, Dale J.
dc.contributor.authorSchnitzler, Christine E.
dc.contributor.authorSchott, Amanda R.
dc.contributor.authorSegal, J. Bradley
dc.contributor.authorShaffer, Christopher D.
dc.contributor.authorSheldon, Kathryn E.
dc.contributor.authorShepard, Erica M.
dc.contributor.authorShepardson, Jonathan W.
dc.contributor.authorShroff, Madav K.
dc.contributor.authorSimmons, Jessica M.
dc.contributor.authorSimms, Erika F.
dc.contributor.authorSimpson, Brandy M.
dc.contributor.authorSinclair, Kathryn M.
dc.contributor.authorSjoholm, Robert L.
dc.contributor.authorSlette, Ingrid J.
dc.contributor.authorSpaulding, Blaire C.
dc.contributor.authorStraub, Clark L.
dc.contributor.authorStukey, Joseph
dc.contributor.authorSughrue, Trevor
dc.contributor.authorTang, Tin-Yun
dc.contributor.authorTatyana, Lyons M.
dc.contributor.authorTaylor, Stephen B.
dc.contributor.authorTaylor, Barbara J.
dc.contributor.authorTemple, Louise M.
dc.contributor.authorThompson, Jasper V.
dc.contributor.authorTokarz, Michael P.
dc.contributor.authorTrapani, Stephanie E.
dc.contributor.authorTroum, Alexander P.
dc.contributor.authorTsay, Jonathan
dc.contributor.authorTubbs, Anthony T.
dc.contributor.authorWalton, Jillian M.
dc.contributor.authorWang, Danielle H.
dc.contributor.authorWang, Hannah
dc.contributor.authorWarner, John R.
dc.contributor.authorWeisser, Emilie G.
dc.contributor.authorWendler, Samantha C.
dc.contributor.authorWeston-Hafer, Kathleen A.
dc.contributor.authorWhelan, Hilary M.
dc.contributor.authorWilliamson, Kurt E.
dc.contributor.authorWillis, Angelica N.
dc.contributor.authorWirtshafter, Hannah S.
dc.contributor.authorWong, Theresa W.
dc.contributor.authorWu, Phillip
dc.contributor.authorYang, Yun jeong
dc.contributor.authorYee, Brandon C.
dc.contributor.authorZaidins, David A.
dc.contributor.authorZhang, Bo
dc.contributor.authorZu´ niga, Melina Y.
dc.contributor.authorHendrix, Roger W.
dc.contributor.authorHatfull, Graham F.
dc.date.accessioned2019-04-01T16:12:08Z
dc.date.available2019-04-01T16:12:08Z
dc.date.issued2011-01-27
dc.description.abstractMycobacteriophages are viruses that infect mycobacterial hosts such as Mycobacterium smegmatis and Mycobacterium tuberculosis. All mycobacteriophages characterized to date are dsDNA tailed phages, and have either siphoviral or myoviral morphotypes. However, their genetic diversity is considerable, and although sixty-two genomes have been sequenced and comparatively analyzed, these likely represent only a small portion of the diversity of the mycobacteriophage population at large. Here we report the isolation, sequencing and comparative genomic analysis of 18 new mycobacteriophages isolated from geographically distinct locations within the United States. Although no clear correlation between location and genome type can be discerned, these genomes expand our knowledge of mycobacteriophage diversity and enhance our understanding of the roles of mobile elements in viral evolution. Expansion of the number of mycobacteriophages grouped within Cluster A provides insights into the basis of immune specificity in these temperate phages, and we also describe a novel example of apparent immunity theft. The isolation and genomic analysis of bacteriophages by freshman college students provides an example of an authentic research experience for novice scientists.en_US
dc.description.sponsorshipNational Institutes of Health Grant GM51975; Howard Hughes Medical Institute. The University of Pittsburgh was supported through a Professor’s grant from HHMI. The Science Education Alliance (SEA) program at HHMI also supported the 12 participating institutions in offering a research-based course for freshman undergraduates. HHMI participated in course design and implementation, and designed tools for data analysis.en_US
dc.description.urihttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0016329en_US
dc.format.extent20 pagesen_US
dc.genrejournal articlesen_US
dc.identifierdoi:10.13016/m2ax5d-prb1
dc.identifier.citationPope WH, Jacobs-Sera D, Russell DA, Peebles CL, Al-Atrache Z, et al. (2011) Expanding the Diversity of Mycobacteriophages: Insights into Genome Architecture and Evolution. PLoS ONE 6(1): e16329. doi:10.1371/journal.pone.0016329en_US
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0016329
dc.identifier.urihttp://hdl.handle.net/11603/13285
dc.language.isoen_USen_US
dc.publisherPLOSen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Biological Sciences Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.rightsAttribution 3.0 United States (CC BY 3.0 US)*
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/us/*
dc.subjectMycobacterium smegmatis and Mycobacterium tuberculosisen_US
dc.subjectdsDNA tailed phagesen_US
dc.subjectsiphoviral or myoviral morphotypesen_US
dc.titleExpanding the Diversity of Mycobacteriophages: Insights into Genome Architecture and Evolutionen_US
dc.typeTexten_US

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