Effect of genetic background on the initiation and progression of mouse prostate cancer driven by MYC overexpression and Pten loss

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dc.contributor.advisorBieberich, Charles J
dc.contributor.authorChin, Alexander
dc.contributor.departmentBiological Sciences
dc.contributor.programBiological Sciences
dc.date.accessioned2022-02-09T15:52:49Z
dc.date.available2022-02-09T15:52:49Z
dc.date.issued2020-01-01
dc.description.abstractLethal human prostate cancer (PCa) frequently harbors MYC gain-of-function and PTEN loss-of-function. In the BMPCFVB mouse model of PCa (Hoxb13-MYC;Hoxb13-Cre;Ptenfl/fl), concurrent genetic deletion of mouse Pten and overexpression of human MYC were sufficient to promote rapid neoplastic growth and metastasis with high penetrance. We hypothesized that breeding the BMPCFVB transgenes onto the C57BL/6J (B6) genetic background would result in slower PCa kinetics. Transgenic offspring with the highest B6 genomic content, determined by genomic SNP and SSLP analyses, were selected for further backcrossing. Our preliminary data suggest that BMPCB6 tumorigenesis involves early-onset and prolonged inflammation, complete penetrance of cystic anterior prostates, and slower and/or multiphase progression as compared to that in the BMPCFVB model. Importantly, BMPCB6 mice develop adenocarcinoma and lymph node metastases histologically similar to BMPCFVB tumors. These data will facilitate future studies aiming to examine strain-dependent differences in tumorigenesis and determine mechanisms underlying PCa resistance in the B6 strain.
dc.formatapplication:pdf
dc.genretheses
dc.identifierdoi:10.13016/m2c3mv-lqwn
dc.identifier.other12368
dc.identifier.urihttp://hdl.handle.net/11603/24204
dc.languageen
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Biological Sciences Department Collection
dc.relation.ispartofUMBC Theses and Dissertations Collection
dc.relation.ispartofUMBC Graduate School Collection
dc.relation.ispartofUMBC Student Collection
dc.sourceOriginal File Name: Chin_umbc_0434M_12368.pdf
dc.subjectC57BL/6
dc.subjectFVB
dc.subjectmetastasis
dc.subjectMYC
dc.subjectProstate cancer
dc.subjectPTEN
dc.titleEffect of genetic background on the initiation and progression of mouse prostate cancer driven by MYC overexpression and Pten loss
dc.typeText
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