Induction of the SOS response by bacteriophage lytic development in Salmonella enterica

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dc.contributor.authorCampoy, Susana
dc.contributor.authorHervàs, Anna
dc.contributor.authorBusquets, Núria
dc.contributor.authorErill, Ivan
dc.contributor.authorTeixidó, Laura
dc.contributor.authorBarbé, Jordi
dc.date.accessioned2021-03-09T17:09:11Z
dc.date.available2021-03-09T17:09:11Z
dc.date.issued2006-05-19
dc.description.abstractInfection of Salmonella enterica with lytic mutants of either P22 or SE1 bacteriophages triggers the expression of its DNA damage-inducible SOS response through a lexA-dependent pathway. This induction of the SOS system strictly requires the presence of the bacteriophage kil gene. Accordingly, plasmid overexpression of the kil gene also promotes the S. enterica SOS network induction. Furthermore, S. enterica Gifsy prophages are induced following the infection with SE1 and P22 lytic derivatives. The observed data reveal a hitherto unknown SOS system-mediated fail-safe mechanism of resident prophages against infection with heteroimmune lytic bacteriophages and suggest a novel role for the kil family of proteins.en
dc.description.sponsorshipThis work was funded by Grants GEN2003-20234-C06-04/NAC from the Ministerio de Educación y Ciencia (MEC) de España, 2005SGR-533 from the Departament d'Universitats, Recerca i Societat de la Informació (DURSI) de la Generalitat de Catalunya and by the Consejo Superior de Investigaciones Científicas (CSIC). N. Busquets and Dra. S. Campoy were recipients of a predoctoral fellowship from the Direcció General d'Universitats de la Generalitat de Catalunya and a post-doctoral contract from INIA-IRTA, respectively. We are deeply indebted to Drs. Lionello Bossi and Nara Figueroa-Bossi for their kindly gift of the S. enterica MA6684 strain and for their critical reading of the manuscript, to Dr. D. I. Andersson for his generous gift of the S. enterica LT2 lexA(Ind) mutant, and to Joan Ruiz and Dra. Pilar Cortés for their excellent technical assistance.en
dc.description.urihttps://www.sciencedirect.com/science/article/pii/S0042682206002339?via%3Dihuben
dc.format.extent8 pagesen
dc.genrejournal articlesen
dc.identifierdoi:10.13016/m2dar1-5gg3
dc.identifier.citationSusana Campoy, Anna Hervàs, Núria Busquets, Ivan Erill, Laura Teixidó, Jordi Barbé, Induction of the SOS response by bacteriophage lytic development in Salmonella enterica, Virology, Volume 351, Issue 2, 2006, Pages 360-367,https://doi.org/10.1016/j.virol.2006.04.001.en
dc.identifier.urihttps://doi.org/10.1016/j.virol.2006.04.001
dc.identifier.urihttp://hdl.handle.net/11603/21113
dc.language.isoenen
dc.publisherElsevieren
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Biological Sciences Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.subjectbacteriophage lytic cycleen
dc.subjectSOS systemen
dc.subjectsalmonella entericaen
dc.subjectresident prophagesen
dc.subjectKil geneen
dc.titleInduction of the SOS response by bacteriophage lytic development in Salmonella entericaen
dc.typeTexten

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