A randomized controlled trial of the effects of working memory training in methadone maintenance patients

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dc.contributor.authorRass, Olga
dc.contributor.authorSchacht, Rebecca L.
dc.contributor.authorBuckheit, Katherine
dc.contributor.authorJohnson, Matthew W.
dc.contributor.authorStrain, Eric C.
dc.contributor.authorMintzer, Miriam Z.
dc.date.accessioned2020-05-22T17:38:22Z
dc.date.available2020-05-22T17:38:22Z
dc.date.issued2015-08-24
dc.description.abstractObjective Working memory impairment in individuals with chronic opioid dependence can play a major role in cognitive and treatment outcomes. Cognitive training targeting working memory shows promise for improved function in substance use disorders. To date, cognitive training has not been incorporated as an adjunctive treatment for opioid dependence. Methods Methadone maintenance patients were randomly assigned to experimental (n = 28) or active control (n = 28) 25-session computerized training and run in parallel. Cognitive and drug use outcomes were assessed before and after training. Results Participants in the experimental condition showed performance improvements on two of four working memory measures, and both groups improved on a third measure of working memory performance. Less frequent drug use was found in the experimental group than in the control group post-training. In contrast to previous findings with stimulant users, no significant effect of working memory training on delay discounting was found using either hypothetical or real rewards. There were no group differences on working memory outcome measures that were dissimilar from the training tasks, suggesting that another mechanism (e.g., increased distress tolerance) may have driven drug use results. Conclusions Working memory training improves performance on some measures of working memory in methadone maintenance patients, and may impact drug use outcomes. Working memory training shows promise in patients with substance use disorders; however, further research is needed to understand the mechanisms through which performance is improved and drug use outcomes are impacted.en_US
dc.description.sponsorshipWe thank Daisy Hussein, Taylor Marcus, and Christina Bittar for protocol management and technical assistance, John Yingling for computer programming assistance and technical support, and Dr. Jeannie-Marie Leoutsakos for assistance with statistical analysis.en_US
dc.description.urihttps://www.sciencedirect.com/science/article/abs/pii/S0376871615016051?via%3Dihuben_US
dc.format.extent23 pagesen_US
dc.genrejournal articles postprintsen_US
dc.identifierdoi:10.13016/m29um4-ksqc
dc.identifier.citationRass, O., Schacht, R. L., Buckheit, K., Johnson, M. W., Strain, E. C., & Mintzer, M. Z. (2015). A randomized controlled trial of the effects of working memory training in methadone maintenance patients. Drug and alcohol dependence, 156, 38–46. https://doi.org/10.1016/j.drugalcdep.2015.08.012en_US
dc.identifier.urihttps://doi.org/10.1016/j.drugalcdep.2015.08.012
dc.identifier.urihttp://hdl.handle.net/11603/18727
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Psychology Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)*
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleA randomized controlled trial of the effects of working memory training in methadone maintenance patientsen_US
dc.typeTexten_US

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