Quantitative Trait Loci With Age-Specific Effects on Fecundity in Drosophila melanogaster

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dc.contributor.authorLeips, Jeff
dc.contributor.authorGilligan, Paul
dc.contributor.authorMackay, Trudy F C
dc.date.accessioned2023-08-07T22:08:48Z
dc.date.available2023-08-07T22:08:48Z
dc.date.issued2006-03-01
dc.description.abstractLife-history theory and evolutionary theories of aging assume the existence of alleles with age-specific effects on fitness. While various studies have documented age-related changes in the genetic contribution to variation in fitness components, we know very little about the underlying genetic architecture of such changes. We used a set of recombinant inbred lines to map and characterize the effects of quantitative trait loci (QTL) affecting fecundity of Drosophila melanogaster females at 1 and 4 weeks of age. We identified one QTL on the second chromosome and one or two QTL affecting fecundity on the third chromosome, but these QTL affected fecundity only at 1 week of age. There was more genetic variation for fecundity at 4 weeks of age than at 1 week of age and there was no genetic correlation between early and late-age fecundity. These results suggest that different loci contribute to the variation in fecundity as the organism ages. Our data provide support for the mutation accumulation theory of aging as applied to reproductive senescence. Comparing the results from this study with our previous work on life-span QTL, we also find evidence that antagonistic pleiotropy may contribute to the genetic basis of senescence in these lines as well.en_US
dc.description.sponsorshipWe thank Stephanie Rollmann for thoughtful discussions on many aspects of the project and Kimberly Hughes, Tashauna Felix, and two anonymous reviewers for their constructive comments on the manuscript. This work was supported by National Science Foundation grant DEB-0349856 and National Research Service Award National Institutes of Health (NIH) grant GM18818-03 to J.L. and NIH grant GM45344 to T.F.C.M.en_US
dc.description.urihttps://academic.oup.com/genetics/article/172/3/1595/6060573en_US
dc.genrejournal articlesen_US
dc.identifierdoi:10.13016/m2vtly-e4ux
dc.identifier.citationJeff Leips and others, Quantitative Trait Loci With Age-Specific Effects on Fecundity in Drosophila melanogaster, Genetics, Volume 172, Issue 3, 1 March 2006, Pages 1595–1605, https://doi.org/10.1534/genetics.105.048520en_US
dc.identifier.urihttps://doi.org/10.1534/genetics.105.048520
dc.identifier.urihttp://hdl.handle.net/11603/29114
dc.language.isoen_USen_US
dc.publisherOxford University Pressen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Biological Sciences Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.en_US
dc.subjectLife-history theoryen_US
dc.subjectEvolutionary theories of agingen_US
dc.subjectQuantitative trait loci (QTL)en_US
dc.subjectFecundity and reproductive senescenceen_US
dc.titleQuantitative Trait Loci With Age-Specific Effects on Fecundity in Drosophila melanogasteren_US
dc.typeTexten_US
dcterms.creatorhttps://orcid.org/0000-0001-8999-6630en_US

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