Association between long-term exposure to ambient air pollution and lesion ischemia in patients with atherosclerosis

dc.contributor.authorXu, Muwu
dc.contributor.authorHou, Zhihui
dc.contributor.authorKoyratty, Nadia
dc.contributor.authorHuang, Conghong
dc.contributor.authorMu, Lina
dc.contributor.authorZhu, Kexin
dc.contributor.authorYu, Guan
dc.contributor.authorLaMonte, Michael J.
dc.contributor.authorBudoff, Matthew J.
dc.contributor.authorKaufman, Joel D.
dc.contributor.authorWang, Meng
dc.contributor.authorLu, Bin
dc.date.accessioned2025-03-11T14:42:41Z
dc.date.available2025-03-11T14:42:41Z
dc.date.issued2023-12-11
dc.description.abstractBackground and aims: Air pollution has been associated with coronary artery disease. The underlying mechanisms were understudied, especially in relation to coronary stenosis leading to myocardial ischemia. Advances in computed tomography (CT) allow for novel quantification of lesion ischemia. We aim to investigate associations between air pollution exposures and fractional flow reserve on CT (CT-FFR), a measure of coronary artery blood flow. Methods: CT-FFR, which defines a ratio of maximal myocardial blood flow compared to its normal value (range: 0–100%), was characterized in 2017 patients with atherosclerosis between 2015 and 2017. Exposures to ozone (O3), nitrogen dioxide (NO2), and fine particulate matter (PM2.5) were estimated using high-resolution exposure models. Linear and logistic regression models were used to assess the association of each air pollutant with CT-FFR and with the prevalence of clinically relevant myocardial ischemia (CT-FFR <75%). Results: Participants were on average 60.1 years old. Annual mean O3, NO2, PM2.5 were 61, 47 and 60 µg/m3, respectively. Mean CT-FFR value was 76.9%. In the main analysis, a higher level of O3 was associated with a lower CT-FFR value (-1.74%, 95% CI: -2.85, -0.63 per 8 µg/m3) and a higher prevalence of myocardial ischemia (odds ratio: 1.32, 95% CI: 1.05–1.65), adjusting for potential confounders such as risk factors and plaque phenotypes, independent of the effects of exposure to NO2 and PM2.5. No associations were observed for PM2.5 or NO2 with CT-FFR. Conclusions: Long-term exposure to O3 is associated with lower CT-FFR value in atherosclerotic patients, indicating higher risk of lesion ischemia.
dc.description.sponsorshipThe authors thank the staff and the participants of the study for their valuable contributions. This study was supported by the Ministry of Science and Technology of China (Grant No. 2016YFC1300400), Chinese national key research and development project (2016-CXGC05-1) and National Institute of Environmental Health Sciences (ES031986) of the United States.
dc.description.urihttps://www.sciencedirect.com/science/article/pii/S0021915023053431
dc.format.extent7 pages
dc.genrejournal articles
dc.genrepostprints
dc.identifierdoi:10.13016/m2lenq-cuki
dc.identifier.citationXu, Muwu, Zhihui Hou, Nadia Koyratty, Conghong Huang, Lina Mu, Kexin Zhu, Guan Yu, et al. “Association between Long-Term Exposure to Ambient Air Pollution and Lesion Ischemia in Patients with Atherosclerosis.” Atherosclerosis 388 (January 1, 2024): 117422. https://doi.org/10.1016/j.atherosclerosis.2023.117422.
dc.identifier.urihttps://doi.org/10.1016/j.atherosclerosis.2023.117422
dc.identifier.urihttp://hdl.handle.net/11603/37761
dc.language.isoen_US
dc.publisherElsevier
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Emergency and Distaster Health Systems
dc.relation.ispartofUMBC Faculty Collection
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International CC BY-NC-ND 4.0 Deed
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAir pollution
dc.subjectLesion ischemia
dc.subjectAtherosclerosis
dc.subjectCT-FFR
dc.subjectUMBC Disaster Health Research Lab
dc.titleAssociation between long-term exposure to ambient air pollution and lesion ischemia in patients with atherosclerosis
dc.typeText
dcterms.creatorhttps://orcid.org/0000-0001-6035-6920

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