Myeloid-Derived Suppressor Cells: Immune-Suppressive Cells That Impair Antitumor Immunity and Are Sculpted by Their Environment

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dc.contributor.authorOstrand-Rosenberg, Suzanne
dc.contributor.authorFenselau, Catherine
dc.date.accessioned2019-02-04T16:15:29Z
dc.date.available2019-02-04T16:15:29Z
dc.date.issued2018-01-15
dc.description.abstractMyeloid-derived suppressor cells (MDSC) are a diverse population of immature myeloid cells that have potent immune-suppressive activity. Studies in both mice and humans have demonstrated that MDSC accumulate in most individuals with cancer, where they promote tumor progression, inhibit antitumor immunity, and are an obstacle to many cancer immunotherapies. As a result, there has been intense interest in understanding the mechanisms and in situ conditions that regulate and sustain MDSC, and the mechanisms MDSC use to promote tumor progression. This article reviews the characterization of MDSC and how they are distinguished from neutrophils, describes the suppressive mechanisms used by MDSC to mediate their effects, and explains the role of proinflammatory mediators and the tumor microenvironment in driving MDSC accumulation, suppressive potency, and survivalen_US
dc.description.sponsorshipThis work was supported by National Institutes of Health Grants RO1CA84232, RO1CA115880, RO1GM021248, and OD019938.en_US
dc.description.urihttp://www.jimmunol.org/content/200/2/422en_US
dc.format.extent11 pagesen_US
dc.genrejournal articles preprintsen_US
dc.identifierdoi:10.13016/m2w7q0-9pwp
dc.identifier.citationSuzanne Ostrand-Rosenberg and Catherine Fenselau, Myeloid-Derived Suppressor Cells: Immune-Suppressive Cells That Impair Antitumor Immunity and Are Sculpted by Their Environment, J Immunol January 15, 2018, 200 (2) 422-431; DOI: https://doi.org/10.4049/jimmunol.1701019en_US
dc.identifier.urihttps://doi.org/10.4049/jimmunol.1701019
dc.identifier.urihttp://hdl.handle.net/11603/12696
dc.language.isoen_USen_US
dc.publisherThe American Association of Immunologists, Incen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Biological Sciences Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.rightsOriginally published in The Journal of Immunology. Suzanne Ostrand-Rosenberg and Catherine Fenselau. 2018. Myeloid-Derived Suppressor Cells: Immune-Suppressive Cells That Impair Antitumor Immunity and Are Sculpted by Their Environment. J. Immunol. Vol: 200 , issue 2 422-431. Copyright © 2019 The American Association of Immunologists, Inc.
dc.subjectMyeloid-Derived suppressor cells (MDSC)en_US
dc.subjectMDSC accumulation in people with canceren_US
dc.subjectMDSC suppressive potency
dc.subjectMDSC survival
dc.subjectdistinguishing MDSC from neutrophils
dc.titleMyeloid-Derived Suppressor Cells: Immune-Suppressive Cells That Impair Antitumor Immunity and Are Sculpted by Their Environmenten_US
dc.title.alternativeImmune suppressive MDSC
dc.typeTexten_US

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