Red cell distribution width, anemia and their associations with white matter integrity among middle-aged urban adults

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dc.contributor.authorBeydoun, May A.
dc.contributor.authorShaked, Danielle
dc.contributor.authorHossain, Sharmin
dc.contributor.authorWeiss, Jordan
dc.contributor.authorBeydoun, Hind A.
dc.contributor.authorMaldonado, Ana
dc.contributor.authorKatzel, Leslie I.
dc.contributor.authorDavatzikos, Christos
dc.contributor.authorGullapalli, Rao P.
dc.contributor.authorSeliger, Stephen L.
dc.contributor.authorErus, Guray
dc.contributor.authorEvans, Michele K.
dc.contributor.authorZonderman, Alan B.
dc.contributor.authorWaldstein, Shari R.
dc.date.accessioned2021-06-07T18:05:48Z
dc.date.available2021-06-07T18:05:48Z
dc.date.issued2021-05-21
dc.description.abstractAnemia (blood hemoglobin (Hb) <13 g/dL among males; <12 g/dL among females) and elevated red cell distribution width (RDW) are potential risk factors for reduced brain white matter integrity (WMI), reflected by lower fractional anisotropy or increased mean diffusivity. Cross-sectional data with exposure-outcome lag time was used, whereby hematological exposures (RDW and Hb) and covariates were compiled from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study with available visit 1 (v₁) (2004-2009) and/or v₂ (2009-2013) data; while diffusion tensor magnetic resonance imaging (dMRI) outcome data were collected at HANDLS SCAN visit (vscan: 2011-2015, n=214, mean follow-up from v₁ ±SD: 5.6±1.8y). Multivariable-adjusted linear regression analyses were conducted, overall, stratifying by sex, and further restricting to the non-anemic for RDW exposures in part of the analyses. Among males, RDW(v₁) was linked with lower global mean fractional anisotropy (standardized effect size b=-0.30, P=0.003, q<0.05; basic model), an association only slightly attenuated with further covariate adjustment. Anemia was not a risk factor for poor WMI, independently of RDW . Ultimately, pending further longitudinal evidence, initial RDW appears to be associated with poorer WMI among males.en_US
dc.description.sponsorshipThis work was supported in part by the Intramural research Program of the NIH, National institute on Aging. This work was also supported by the National Institutes of Health, R01-AG034161 to S.R.W, ZIA–AG000513 to M.K.E. and A.B.Z., and The University of Maryland Claude D. Pepper Older Americans Independence Center (NIH grant P30 AG028747).en_US
dc.description.urihttps://www.sciencedirect.com/science/article/abs/pii/S0197458021001585#!en_US
dc.format.extent2 filesen_US
dc.genrejournal articles postprintsen_US
dc.identifierdoi:10.13016/m2kozb-wffk
dc.identifier.citationBeydoun, May A.; Shaked, Danielle; Hossain, Sharmin; Weiss, Jordan; Beydoun, Hind A.; Maldonado, Ana; Katzel, Leslie I.; Davatzikos, Christos; Gullapalli, Rao P.; Seliger, Stephen L.; Erus, Guray; Evans, Michele K.; Zonderman, Alan B.; Waldstein, Shari R.; Red cell distribution width, anemia and their associations with white matter integrity among middle-aged urban adults; Neurobiology of Aging, 2021; https://doi.org/10.1016/j.neurobiolaging.2021.05.004en_US
dc.identifier.urihttps://doi.org/10.1016/j.neurobiolaging.2021.05.004
dc.identifier.urihttp://hdl.handle.net/11603/21693
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Psychology Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.relation.ispartofUMBC Student Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.rightsPublic Domain Mark 1.0*
dc.rightsThis work was written as part of one of the author's official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law.
dc.rights.urihttp://creativecommons.org/publicdomain/mark/1.0/*
dc.titleRed cell distribution width, anemia and their associations with white matter integrity among middle-aged urban adultsen_US
dc.typeTexten_US

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