Everybody’s welcome: The big tent approach to epigenetic drug discovery
| dc.contributor.author | Green, Erin | |
| dc.contributor.author | Gozani, Or | |
| dc.date.accessioned | 2023-01-26T16:14:57Z | |
| dc.date.available | 2023-01-26T16:14:57Z | |
| dc.date.issued | 2011-09-20 | |
| dc.description.abstract | The rapid expansion of epigenetics research is fueled by the increasing understanding that epigenetic processes are critical to regulating cellular development and dysfunction of epigenetic programs is responsible for a diverse set of human pathologies, including cancer, autoimmune and neurodegenerative diseases. The expansive set of components contributing to epigenetic disease mechanisms and the often reversible nature of epigenetic lesions provide prime opportunities for the development of novel therapeutic strategies. Here, we provide an overview of epigenetics and its relationship to disease, discuss current epigenetics-based therapies and suggest new avenues for the identification of therapies targeting deregulated epigenetic programs in disease. | en |
| dc.description.uri | https://www.sciencedirect.com/science/article/abs/pii/S1740677311000301?via%3Dihub | en |
| dc.format.extent | 11 pages | en |
| dc.genre | journal articles | en |
| dc.genre | postprints | en |
| dc.identifier | doi:10.13016/m2lxff-pghn | |
| dc.identifier.citation | Green, Erin M, and Or Gozani. “Everybody's welcome: The big tent approach to epigenetic drug discovery.” Drug discovery today. Therapeutic strategies vol. 9,2-3 (2012): e75-e81. doi:10.1016/j.ddstr.2011.08.002 | en |
| dc.identifier.uri | https://doi.org/10.1016/j.ddstr.2011.08.002 | |
| dc.identifier.uri | http://hdl.handle.net/11603/26718 | |
| dc.language.iso | en | en |
| dc.publisher | Elsevier | en |
| dc.relation.isAvailableAt | The University of Maryland, Baltimore County (UMBC) | |
| dc.relation.ispartof | UMBC Biological Sciences Department Collection | |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) | * |
| dc.rights | This item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author. | en |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
| dc.title | Everybody’s welcome: The big tent approach to epigenetic drug discovery | en |
| dc.type | Text | en |
| dcterms.creator | https://orcid.org/0000-0003-3923-6726 | en |