Disparities in Diffuse Cortical White Matter Integrity Between Socioeconomic Groups

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dc.contributorBarnes, Lisa L.
dc.contributor.authorShaked, Danielle
dc.contributor.authorLeibel, Daniel K.
dc.contributor.authorKatzel, Leslie I.
dc.contributor.authorDavatzikos, Christos
dc.contributor.authorGullapalli, Rao P.
dc.contributor.authorSeliger, Stephen L.
dc.contributor.authorErus, Guray
dc.contributor.authorEvans, Michele K.
dc.contributor.authorZonderman, Alan B.
dc.contributor.authorWaldstein, Shari R.
dc.date.accessioned2019-10-10T14:47:09Z
dc.date.available2019-10-10T14:47:09Z
dc.date.issued2019-06-12
dc.description.abstractThere is a growing literature demonstrating a link between lower socioeconomic status (SES) and poorer neuroanatomical health, such as smaller total and regional gray and white matter volumes, as well as greater white matter lesion volumes. Little is known, however, about the relation between SES and white matter integrity. Here we examined the relation between SES and white matter integrity of the brain’s primary cortical regions, and evaluated potential moderating influences of age and self-identified race. Participants were 192 neurologically intact, community-dwelling African American and White adults (mean age = 52 years; 44% male, 60% White, low SES = 52%) from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) SCAN study. Participants underwent 3.0-T cranial magnetic resonance imaging. Diffusion tensor imaging was used to estimate regional fractional anisotropy (FA) to quantify the brain’s white matter integrity and trace to capture diffusivity. Multiple regression analyses examined independent and interactive associations of SES, age, and race with FA of the frontal, temporal, parietal, and occipital lobes bilaterally. Sensitivity analyses assessed the influence of several biopsychosocial risk factors on these associations. Exploratory analyses examined these relations with trace and using additional SES indicators. Results indicated there were no significant interactions of SES, age, and race for any region. Individuals with low SES had lower FA in all regions, and higher trace in the right and left frontal, right and left temporal, and left occipital lobes. Findings remained largely unchanged after inclusion of sensitivity variables. Older age was associated with lower FA and greater trace for all regions, except for the right temporal lobe with FA. No main effects were found for race in FA, and Whites had higher trace values in the parietal lobes. Novel findings of this study indicate that relative to the high SES group, low SES was associated with poorer white matter integrity and greater diffusivity. These results may, in part, reflect exposures to various biopsychosocial risk factors experienced by those of lower SES across the lifespan, and may help explain the preponderance of cognitive and functional disparities between socioeconomic groups.en_US
dc.description.sponsorshipThis work was supported by the National Institutes of Health. R01-AG034161 and P30 AG028747 to SW, ZIA–AG000513 to ME and AZ, and the University of Maryland Claude D. Pepper Older Americans Independence Center (P30 AG028747).en_US
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fnhum.2019.00198/fullen_US
dc.format.extent14 pagesen_US
dc.genrejournal articlesen_US
dc.identifierdoi:10.13016/m2qioh-pfsl
dc.identifier.citationShaked D, Leibel DK, Katzel LI, Davatzikos C, Gullapalli RP, Seliger SL, Erus G, Evans MK, Zonderman AB and Waldstein SR (2019) Disparities in Diffuse Cortical White Matter Integrity Between Socioeconomic Groups. Front. Hum. Neurosci. 13:198. doi: 10.3389/fnhum.2019.00198en_US
dc.identifier.urihttps://doi.org/10.3389/fnhum.2019.00198
dc.identifier.urihttp://hdl.handle.net/11603/15022
dc.language.isoen_USen_US
dc.publisherFrontiers Media S.A.en_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Psychology Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.relation.ispartofUMBC Student Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.rightsAttribution 4.0 International (CC BY 4.0)*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectwhite matter integrityen_US
dc.subjecthealth disparitiesen_US
dc.subjectdiffusion tensor imagingen_US
dc.subjectsocioeconomic statusen_US
dc.subjectraceen_US
dc.subjectageen_US
dc.subjectneuroanatomical healthen_US
dc.titleDisparities in Diffuse Cortical White Matter Integrity Between Socioeconomic Groupsen_US
dc.typeTexten_US

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