Choose your own adventure: The role of histone modifications in yeast cell fate

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dc.contributor.authorJaiswal, Deepika
dc.contributor.authorTurniansky, Rashi
dc.contributor.authorGreen, Erin
dc.date.accessioned2023-01-25T20:47:40Z
dc.date.available2023-01-25T20:47:40Z
dc.date.issued2017-06-15
dc.description.abstractWhen yeast cells are challenged by a fluctuating environment, signaling networks activate differentiation programs that promote their individual or collective survival. These programs include the initiation of meiotic sporulation, the formation of filamentous growth structures and the activation of programmed cell death pathways. The establishment and maintenance of these distinct cell fates are driven by massive gene expression programs that promote the necessary changes in morphology and physiology. While these genomic reprogramming events depend on a specialized network of transcription factors, a diverse set of chromatin regulators, including histone-modifying enzymes, chromatin remodelers and histone variants, also play essential roles. Here, we review the broad functions of histone modifications in initiating cell fate transitions, with particular focus on their contribution to the control of expression of key genes required for the differentiation programs and chromatin reorganization that accompanies these cell fates.en_US
dc.description.sponsorshipThe authors acknowledge members of the Green lab for fruitful discussions and comments on the manuscript. This work was supported in part by NIH R03AG052018 and a UMBC START award to EMG.en_US
dc.description.urihttps://www.sciencedirect.com/science/article/abs/pii/S0022283616304338?via%3Dihuben_US
dc.format.extent23 pagesen_US
dc.genrejournal articlesen_US
dc.genrepostprintsen_US
dc.identifierdoi:10.13016/m2ifvf-7qyd
dc.identifier.citationJaiswal, Deepika et al. “Choose Your Own Adventure: The Role of Histone Modifications in Yeast Cell Fate.” Journal of molecular biology vol. 429,13 (2017): 1946-1957. doi:10.1016/j.jmb.2016.10.018en_US
dc.identifier.urihttps://doi.org/10.1016/j.jmb.2016.10.018
dc.identifier.urihttp://hdl.handle.net/11603/26713
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Biological Sciences Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.relation.ispartofUMBC Student Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)*
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleChoose your own adventure: The role of histone modifications in yeast cell fateen_US
dc.typeTexten_US
dcterms.creatorhttps://orcid.org/0000-0002-6514-7535en_US
dcterms.creatorhttps://orcid.org/0000-0003-3923-6726en_US

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