Linking Copper-Associated Signal Transduction Systems with Their Environment in Marine Bacteria

Gautam, Pratima; Erill, Ivan; Cusick, Kathleen

Linking Copper-Associated Signal Transduction Systems with Their Environment in Marine Bacteria

dc.contributor.author	Gautam, Pratima
dc.contributor.author	Erill, Ivan
dc.contributor.author	Cusick, Kathleen
dc.date.accessioned	2023-05-18T15:40:50Z
dc.date.available	2023-05-18T15:40:50Z
dc.date.issued	2023-04-13
dc.description.abstract	Copper is an essential trace element for living cells. However, copper can be potentially toxic for bacterial cells when it is present in excess amounts due to its redox potential. Due to its biocidal properties, copper is prevalent in marine systems due to its use in antifouling paints and as an algaecide. Thus, marine bacteria must possess means of sensing and responding to both high copper levels and those in which it is present at only typical trace metal levels. Bacteria harbor diverse regulatory mechanisms that respond to intracellular and extracellular copper and maintain copper homeostasis in cells. This review presents an overview of the copper-associated signal transduction systems in marine bacteria, including the copper efflux systems, detoxification, and chaperone mechanisms. We performed a comparative genomics study of the copper-regulatory signal transduction system on marine bacteria to examine the influence of the environment on the presence, abundance, and diversity of copper-associated signal transduction systems across representative phyla. Comparative analyses were performed among species isolated from sources, including seawater, sediment, biofilm, and marine pathogens. Overall, we observed many putative homologs of copper-associated signal transduction systems from various copper systems across marine bacteria. While the distribution of the regulatory components is mainly influenced by phylogeny, our analyses identified several intriguing trends: (1) Bacteria isolated from sediment and biofilm displayed an increased number of homolog hits to copper-associated signal transduction systems than those from seawater. (2) A large variability exists for hits to the putative alternate σ factor CorE hits across marine bacteria. (3) Species isolated from seawater and marine pathogens harbored fewer CorE homologs than those isolated from the sediment and biofilm.	en_US
dc.description.sponsorship	This work was supported by UMBC’s internal funding for KC.	en_US
dc.description.uri	https://www.mdpi.com/2076-2607/11/4/1012	en_US
dc.format.extent	20 pages	en_US
dc.genre	journal articles	en_US
dc.identifier	doi:10.13016/m2gdm3-y5hr
dc.identifier.citation	Gautam, Pratima, Ivan Erill, and Kathleen D. Cusick. 2023. "Linking Copper-Associated Signal Transduction Systems with Their Environment in Marine Bacteria" Microorganisms 11, no. 4: 1012. https://doi.org/10.3390/microorganisms11041012	en_US
dc.identifier.uri	https://doi.org/10.3390/microorganisms11041012
dc.identifier.uri	http://hdl.handle.net/11603/28003
dc.language.iso	en_US	en_US
dc.publisher	MDPI	en_US
dc.relation.isAvailableAt	The University of Maryland, Baltimore County (UMBC)
dc.relation.ispartof	UMBC Biological Sciences Department Collection
dc.relation.ispartof	UMBC Faculty Collection
dc.rights	This item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.	en_US
dc.rights	Attribution 4.0 International (CC BY 4.0)	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.title	Linking Copper-Associated Signal Transduction Systems with Their Environment in Marine Bacteria	en_US
dc.type	Text	en_US
dcterms.creator	https://orcid.org/0000-0002-7280-7191	en_US
dcterms.creator	https://orcid.org/0000-0001-7224-3472	en_US