Recombinant Newcastle Disease Virus (NDV) Expressing Sigma C Protein of Avian Reovirus (ARV) Protects against Both ARV and NDV in Chickens

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dc.contributor.authorSaikia, Deep Prakash
dc.contributor.authorYadav, Kalpana
dc.contributor.authorPathak, Dinesh C.
dc.contributor.authorRamamurthy, Narayan
dc.contributor.authorD’Silva, Ajai Lawrence
dc.contributor.authorMarriappan, Asok Kumar
dc.contributor.authorRamakrishnan, Saravanan
dc.contributor.authorVakharia, Vikram N.
dc.contributor.authorChellappa, Madhan Mohan
dc.contributor.authorDey, Sohini
dc.date.accessioned2019-10-18T14:54:13Z
dc.date.available2019-10-18T14:54:13Z
dc.date.issued2019-09-10
dc.description.abstractNewcastle disease (ND) and avian reovirus (ARV) infections are a serious threat to the poultry industry, which causes heavy economic losses. The mesogenic NDV strain R2B is commonly used as a booster vaccine in many Asian countries to control the disease. In this seminal work, a recombinant NDV strain R2B expressing the sigma C (σC) gene of ARV (rNDV-R2B-σC) was generated by reverse genetics, characterized in vitro and tested as a bivalent vaccine candidate in chickens. The recombinant rNDV-R2B-σC virus was attenuated as compared to the parent rNDV-R2B virus as revealed by standard pathogenicity assays. The generated vaccine candidate, rNDV-R2B-σC, could induce both humoral and cell mediated immune responses in birds and gave complete protection against virulent NDV and ARV challenges. Post-challenge virus shedding analysis revealed a drastic reduction in NDV shed, as compared to unvaccinated birdsen_US
dc.description.sponsorshipThe research work was supported by grants from the Department of Biotechnology, Government of India (BT/PR15373/AAQ/57/116/2011 and BT/PR21576/ADV/90/249/2016) and National Agricultural Science Fund, ICAR (NFBSFARA/BS-3010).en_US
dc.description.urihttps://www.mdpi.com/2076-0817/8/3/145en_US
dc.format.extent21 pagesen_US
dc.genrejournal articlesen_US
dc.identifierdoi:10.13016/m2toyz-kto8
dc.identifier.citationSaikia, D.P.; Yadav, K.; Pathak, D.C.; Ramamurthy, N.; D’Silva, A.L.; Marriappan, A.K.; Ramakrishnan, S.; Vakharia, V.N.; Chellappa, M.M.; Dey, S. Recombinant Newcastle Disease Virus (NDV) Expressing Sigma C Protein of Avian Reovirus (ARV) Protects against Both ARV and NDV in Chickens. Pathogens 2019, 8, 145.en_US
dc.identifier.urihttps://doi.org/10.3390/pathogens8030145
dc.identifier.urihttp://hdl.handle.net/11603/15913
dc.language.isoen_USen_US
dc.publisherMDPIen_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Department of Marine Biotechnology
dc.relation.ispartofUMBC Faculty Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.rightsAttribution 4.0 International (CC BY 4.0)*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectnewcastle disease virusen_US
dc.subjectavian reovirus-σC proteinen_US
dc.subjectbivalent vaccine candidateen_US
dc.subjecthumoral and cell mediated immune responsesen_US
dc.subjectprotection efficacyen_US
dc.titleRecombinant Newcastle Disease Virus (NDV) Expressing Sigma C Protein of Avian Reovirus (ARV) Protects against Both ARV and NDV in Chickensen_US
dc.typeTexten_US

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