Biotransformation novel advances – 2021 year in review

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https://www.tandfonline.com/doi/full/10.1080/03602532.2022.2097253

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https://doi.org/10.1080/03602532.2022.2097253
 http://hdl.handle.net/11603/29815

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UMBC Chemistry & Biochemistry Department

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https://orcid.org/0000-0002-7221-7060

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2022-08-30

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journal articles
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Citation of Original Publication

S. Cyrus Khojasteh, Upendra A. Argikar, Sungjoon Cho, Rachel Crouch, Carley J. S. Heck, Kevin M. Johnson, Amit S. Kalgutkar, Lloyd King, Hlaing (Holly) Maw, Herana Kamal Seneviratne, Shuai Wang, Cong Wei, Donglu Zhang & Klarissa D. Jackson (2022) Biotransformation novel advances – 2021 year in review, Drug Metabolism Reviews, 54:3, 207-245, DOI: 10.1080/03602532.2022.2097253

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Abstract

Biotransformation field is constantly evolving with new molecular structures and discoveries of metabolic pathways that impact efficacy and safety. Recent review by Kramlinger et al. (2022) nicely captures the future (and the past) of highly impactful science of biotransformation (see the first article). Based on the selected articles, this review was categorized into three sections: (1) new modalities biotransformation, (2) drug discovery biotransformation, and (3) drug development biotransformation (Table 1).