A roadmap to engineering antiviral natural products synthesis in microbe
| dc.contributor.author | Ma, Jingbo | |
| dc.contributor.author | Gu, Yang | |
| dc.contributor.author | Xu, Peng | |
| dc.date.accessioned | 2020-08-17T16:06:41Z | |
| dc.date.available | 2020-08-17T16:06:41Z | |
| dc.date.issued | 2020-08-12 | |
| dc.description.abstract | Natural products continue to be the inspirations for us to discover and acquire new drugs. The seemingly unstoppable viruses have kept records high to threaten human health and well-being. The diversity and complexity of natural products (NPs) offer remarkable efficacy and specificity to target viral infection steps and serve as excellent source for antiviral agents. The discovery and production of antiviral NPs remain challenging due to low abundance in their native hosts. Reconstruction of NP biosynthetic pathways in microbes is a promising solution to overcome this limitation. In this review, we surveyed 23 most prominent NPs (from more than 200 antiviral NP candidates) with distinct antiviral mode of actions and summarized the recent metabolic engineering effort to produce these compounds in various microbial hosts. We envision that the scalable and low-cost production of novel antiviral NPs, enabled by metabolic engineering, may light the hope to control and eradicate the deadliest viruses that plague our society and humanity. | en_US |
| dc.description.sponsorship | This work was supported by the Bill & Melinda Gates Foundation (grantnumber OPP1188443) and the Cellular & Biochem Engineering Program ofthe National Science Foundation under grant no.1805139. | en_US |
| dc.description.uri | https://www.sciencedirect.com/science/article/pii/S0958166920300963?via%3Dihub | en_US |
| dc.format.extent | 10 pages | en_US |
| dc.genre | journal articles | en_US |
| dc.identifier | doi:10.13016/m2oq5t-0sc7 | |
| dc.identifier.citation | Jingbo Ma, Yang Gu and Peng Xu, A roadmap to engineering antiviral natural products synthesis in microbes, Current Opinion in Biotechnology Volume 66, Pages 140-149 (2020), https://doi.org/10.1016/j.copbio.2020.07.008 | en_US |
| dc.identifier.uri | https://doi.org/10.1016/j.copbio.2020.07.008 | |
| dc.identifier.uri | http://hdl.handle.net/11603/19437 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Elsevier | en_US |
| dc.relation.isAvailableAt | The University of Maryland, Baltimore County (UMBC) | |
| dc.relation.ispartof | UMBC Chemical, Biochemical & Environmental Engineering Department Collection | |
| dc.relation.ispartof | UMBC Faculty Collection | |
| dc.rights | This item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author. | |
| dc.rights | Attribution 4.0 International | * |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
| dc.title | A roadmap to engineering antiviral natural products synthesis in microbe | en_US |
| dc.type | Text | en_US |