Lanthanide-doped nanoparticles for hybrid x-ray/optical imaging
| dc.contributor.author | Sudheendra, L. | |
| dc.contributor.author | Das, Gautom Kumar | |
| dc.contributor.author | Li, C. | |
| dc.contributor.author | Cherry, Simon R. | |
| dc.contributor.author | Kennedy, Ian M. | |
| dc.date.accessioned | 2024-03-14T22:54:42Z | |
| dc.date.available | 2024-03-14T22:54:42Z | |
| dc.date.issued | 2013-02-21 | |
| dc.description | SPIE BiOS, 2013, San Francisco, California, United States. | |
| dc.description.abstract | Some lanthanide-doped nanoparticles can absorb X-ray radiation and emit in the visible to near infrared spectrum via a down-conversion mechanism, making them a potentially valuable agent for in vivo imaging studies. We have studied a series of Gd³⁺ and Eu³⁺compositions in lanthanide fluorides to optimize the emission from Eu³⁺ upon X-ray excitation. The optimum concentration of Eu³⁺ that produced the most intense emission in NaGdF₄ was found to be 15% molar concentration. The impact of the crystallographic phases (i.e. cubic or hexagonal) on the optical emission was investigated. Furthermore, an attempt to include a sensitizer (i.e Ce³⁺) in NaGdF₄:Eu resulted in a reduction in the emission following X-ray excitation. A surface coating of NaGdF₄:Eu nanoparticles with a gold shell showed a similar decrease in luminescence intensity by a factor of two although the gold shell offers other advantages in biomedical applications. | |
| dc.description.sponsorship | We acknowledge the support of the W. M. Keck Foundation for a research grant in science and engineering. The project was also supported by the National Institutes of Health under grant R21 EB013828 and the National Research Initiative of the USDA Cooperative State Research, Education and Extension Service, grant number 2009-35603-05070. In addition, the project was supported by Award Number P42 ES004699 from the National Institute of Environmental Health Sciences. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Environmental Health Sciences or the National Institutes of Health. | |
| dc.description.uri | https://www.spiedigitallibrary.org/conference-proceedings-of-spie/8596/85960D/Lanthanide-doped-nanoparticles-for-hybrid-x-rayoptical-imaging/10.1117/12.2005250.full | |
| dc.format.extent | 8 pages | |
| dc.genre | conference papers and proceedings | |
| dc.identifier | doi:10.13016/m2tip0-25ig | |
| dc.identifier.citation | Sudheendra, L., Gautom K. Das, C. Li, Simon R. Cherry, and Ian M. Kennedy. “Lanthanide-Doped Nanoparticles for Hybrid x-Ray/Optical Imaging.” In Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications V, 8596:76–83. SPIE, 2013. https://doi.org/10.1117/12.2005250. | |
| dc.identifier.uri | https://doi.org/10.1117/12.2005250 | |
| dc.identifier.uri | http://hdl.handle.net/11603/32040 | |
| dc.publisher | SPIE | |
| dc.relation.isAvailableAt | The University of Maryland, Baltimore County (UMBC) | |
| dc.relation.ispartof | UMBC Chemical, Biochemical & Environmental Engineering Department Collection | |
| dc.rights | ©(2013) Society of Photo-Optical Instrumentation Engineers (SPIE). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. | |
| dc.title | Lanthanide-doped nanoparticles for hybrid x-ray/optical imaging | |
| dc.type | Text | |
| dcterms.creator | https://orcid.org/0000-0001-5760-4110 |