Odors Detected by Mice Deficient in Cyclic Nucleotide-Gated Channel Subunit A2 Stimulate the Main Olfactory System
| dc.contributor.author | Lin, Weihong | |
| dc.contributor.author | Arellano, Julie | |
| dc.contributor.author | Slotnick, Burton | |
| dc.contributor.author | Restrepo, Diego | |
| dc.date.accessioned | 2021-03-29T18:14:29Z | |
| dc.date.available | 2021-03-29T18:14:29Z | |
| dc.date.issued | 2004-04-07 | |
| dc.description.abstract | It is believed that odor transduction in the mammalian main olfactory system only involves the cAMP-signaling pathway. Here, we report on odor responsiveness in mice with a disrupted cyclic nucleotide-gated (CNG) channel subunit A2. Several odorants, including putative pheromones, can be detected and discriminated by these mice behaviorally. These odors elicit responses in the olfactory epithelium, main olfactory bulb, and olfactory (piriform) cortex of CNGA2 knock-out mice. In addition, responses to odors detected by CNGA2 knock-out mice are relatively insensitive to inhibitors of the cAMP pathway. These results provide strong evidence that cAMP-independent pathways in the main olfactory system of mammals participate in detecting a subset of odors | en_US |
| dc.description.sponsorship | This work was supported by National Institutes of Health Grants DC00566, DC04657, DC006070 (D.R.), DC0043 (W.L.), and MH6118 (B.S.). We thank Drs. Tom Finger, Sue Kinnamon, Tatsuya Ogura, and Michele Schaefer for discussion, Audrey Hathaway for technical assistance, Dr. William Cain for assistance with estimation of air concentration of odorants, Drs. John Ngai and Randall Reed for providing us with knock-out mice, and Dr. Gene Delay for help on the initial phase of the behavioral experiments and discussion. | en_US |
| dc.description.uri | https://www.jneurosci.org/content/24/14/3703 | en_US |
| dc.format.extent | 8 pages | en_US |
| dc.genre | journal articles | en_US |
| dc.identifier | doi:10.13016/m2ez93-c56n | |
| dc.identifier.citation | Weihong Lin, Julie Arellano, Burton Slotnick, Diego Restrepo, Odors Detected by Mice Deficient in Cyclic Nucleotide-Gated Channel Subunit A2 Stimulate the Main Olfactory System, Journal of Neuroscience 7 April 2004, 24 (14) 3703-3710; DOI: 10.1523/JNEUROSCI.0188-04.2004 | en_US |
| dc.identifier.uri | https://doi.org/10.1523/JNEUROSCI.0188-04.2004 | |
| dc.identifier.uri | http://hdl.handle.net/11603/21244 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Society for Neuroscience | en_US |
| dc.relation.isAvailableAt | The University of Maryland, Baltimore County (UMBC) | |
| dc.relation.ispartof | UMBC Biological Sciences Department Collection | |
| dc.rights | This item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author. | |
| dc.title | Odors Detected by Mice Deficient in Cyclic Nucleotide-Gated Channel Subunit A2 Stimulate the Main Olfactory System | en_US |
| dc.type | Text | en_US |