Bridging the divide between neuroprosthetic design, tissue engineering and neurobiology

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dc.contributor.authorLeach, Jennie B.
dc.contributor.authorAchyuta, Anil Kumar H.
dc.contributor.authorMurthy, Shashi K.
dc.date.accessioned2018-12-14T17:13:44Z
dc.date.available2018-12-14T17:13:44Z
dc.date.issued2010-02-08
dc.description.abstractNeuroprosthetic devices have made a major impact in the treatment of a variety of disorders such as paralysis and stroke. However, a major impediment in the advancement of this technology is the challenge of maintaining device performance during chronic implantation (months to years) due to complex intrinsic host responses such as gliosis or glial scarring. The objective of this review is to bring together research communities in neurobiology, tissue engineering, and neuroprosthetics to address the major obstacles encountered in the translation of neuroprosthetics technology into long-term clinical use. This article draws connections between specific challenges faced by current neuroprosthetics technology and recent advances in the areas of nerve tissue engineering and neurobiology. Within the context of the device–nervous system interface and central nervous system implants, areas of synergistic opportunity are discussed, including platforms to present cells with multiple cues, controlled delivery of bioactive factors, three-dimensional constructs and in vitro models of gliosis and brain injury, nerve regeneration strategies, and neural stem/progenitor cell biology. Finally, recent insights gained from the fields of developmental neurobiology and cancer biology are discussed as examples of exciting new biological knowledge that may provide fresh inspiration toward novel technologies to address the complexities associated with long-term neuroprosthetic device performance.en_US
dc.description.sponsorshipThis work was supported by NIH-NINDS (1R01NS065205 to Jennie B. Leach; 1R44NS047952 to GVD Corp. and subcontract to Shashi K. Murthy) and the Henry Luce Foundation (Jennie B. Leach).en_US
dc.description.urihttps://www.frontiersin.org/articles/10.3389/neuro.16.018.2009/fullen_US
dc.format.extent19 pagesen_US
dc.genrejournal articlesen_US
dc.identifierdoi:10.13016/M2DJ58M5K
dc.identifier.citationJennie B. Leach, Anil Kumar H. Achyuta and Shashi K. Murthy, Bridging the divide between neuroprosthetic design, tissue engineering and neurobiology , Frontiers in Neuroengineering, 08 February 2010 , https://doi.org/10.3389/neuro.16.018.2009en_US
dc.identifier.urihttp://hdl.handle.net/11603/12266
dc.language.isoen_USen_US
dc.publisherFrontiers Media S.A.en_US
dc.relation.isAvailableAtThe University of Maryland, Baltimore County (UMBC)
dc.relation.ispartofUMBC Chemical, Biochemical & Environmental Engineering Department Collection
dc.relation.ispartofUMBC Faculty Collection
dc.rightsThis item is likely protected under Title 17 of the U.S. Copyright Law. Unless on a Creative Commons license, for uses protected by Copyright Law, contact the copyright holder or the author.
dc.rightsAttribution 4.0 International (CC BY 4.0)*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectneuroprostheticen_US
dc.subjectgliosisen_US
dc.subjectnerve regenerationen_US
dc.subjectsignal degradationen_US
dc.subjectUtah electrodeen_US
dc.subjectdrug deliveryen_US
dc.subjectneural progenitoren_US
dc.subjectneural probesen_US
dc.titleBridging the divide between neuroprosthetic design, tissue engineering and neurobiologyen_US
dc.typeTexten_US

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