Melatonin for Sedative Withdrawal in Older Patients with Primary Insomnia: a Randomized Double-Blind Placebo-Controlled Trial

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dc.contributor.authorLähteenmäki, Ritva
dc.contributor.authorPuustinen, Juha
dc.contributor.authorVahlberg, Tero
dc.contributor.authorLyles, Alan
dc.contributor.authorNeuvonen, Pertti J
dc.contributor.authorPartinen, Markku
dc.contributor.authorRäihä, Ismo
dc.contributor.authorKivelä, Sirkka-Liisa
dc.date.accessioned2018-04-03T17:26:44Z
dc.date.available2018-04-03T17:26:44Z
dc.date.issued2014-06
dc.description.abstractWe compared the efficacy of melatonin and placebo as adjuvants in the withdrawal of patients from long term temazepam, zopiclone or zolpidem (here ‘BZD’) use. Gradual dose reduction of BZDs combined with CRM or placebo, and psychosocial support produced high short term and moderate long term BZD abstinence. CRM showed no withdrawal benefit compared with placebo.en
dc.format.extent17en
dc.genrejournal articlesen
dc.identifierdoi:10.13016/M24F1MK95
dc.identifier.citationLähteenmäki, R., Puustinen, J., Vahlberg T., Lyles, A., Neuvonen, P.J., Partinen P., Räihä, I., Kivelä, S. (2014) Melatonin for Sedative Withdrawal in Older Patients with Primary Insomnia: a Randomised Double-Blind Placebo-Controlled Trial. British Journal of Clinical Pharmacology. doi: 10.1111/bcp.12294.en
dc.identifier.urihttp://hdl.handle.net/11603/7910
dc.language.isoenen
dc.publisherBritish Journal of Clinical Pharmacologyen
dc.relation.isAvailableAtUniversity of Baltimore
dc.subjectcontrolled trialen
dc.subjectmelatoninen
dc.subjecttemazepamen
dc.subjectwithdrawalen
dc.subjectzolpidemen
dc.subjectzopicloneen
dc.titleMelatonin for Sedative Withdrawal in Older Patients with Primary Insomnia: a Randomized Double-Blind Placebo-Controlled Trialen
dc.typeTexten

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