Melatonin for Sedative Withdrawal in Older Patients with Primary Insomnia: a Randomized Double-Blind Placebo-Controlled Trial

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dc.contributor.authorLähteenmäki, Ritva
dc.contributor.authorPuustinen, Juha
dc.contributor.authorVahlberg, Tero
dc.contributor.authorLyles, Alan
dc.contributor.authorNeuvonen, Pertti J
dc.contributor.authorPartinen, Markku
dc.contributor.authorRäihä, Ismo
dc.contributor.authorKivelä, Sirkka-Liisa
dc.date.accessioned2018-04-03T17:26:44Z
dc.date.available2018-04-03T17:26:44Z
dc.date.issued2014-06
dc.description.abstractWe compared the efficacy of melatonin and placebo as adjuvants in the withdrawal of patients from long term temazepam, zopiclone or zolpidem (here ‘BZD’) use. Gradual dose reduction of BZDs combined with CRM or placebo, and psychosocial support produced high short term and moderate long term BZD abstinence. CRM showed no withdrawal benefit compared with placebo.en_US
dc.format.extent17en_US
dc.genrejournal articlesen_US
dc.identifierdoi:10.13016/M24F1MK95
dc.identifier.citationLähteenmäki, R., Puustinen, J., Vahlberg T., Lyles, A., Neuvonen, P.J., Partinen P., Räihä, I., Kivelä, S. (2014) Melatonin for Sedative Withdrawal in Older Patients with Primary Insomnia: a Randomised Double-Blind Placebo-Controlled Trial. British Journal of Clinical Pharmacology. doi: 10.1111/bcp.12294.en_US
dc.identifier.urihttp://hdl.handle.net/11603/7910
dc.language.isoen_USen_US
dc.publisherBritish Journal of Clinical Pharmacologyen_US
dc.relation.isAvailableAtUniversity of Baltimore
dc.subjectcontrolled trialen_US
dc.subjectmelatoninen_US
dc.subjecttemazepamen_US
dc.subjectwithdrawalen_US
dc.subjectzolpidemen_US
dc.subjectzopicloneen_US
dc.titleMelatonin for Sedative Withdrawal in Older Patients with Primary Insomnia: a Randomized Double-Blind Placebo-Controlled Trialen_US
dc.typeTexten_US

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